Sex differences in in-hospital outcomes in hypertrophic cardiomyopathy: A nationwide analysis

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Current Problems in Cardiology Pub Date : 2025-09-10 DOI:10.1016/j.cpcardiol.2025.103172

Ahmed M. Saad MD , Mohammed Abozenah MD , Colby Salerno DO , Andrew M. Goldsweig MD, MS

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引用次数: 0

Abstract

Background

Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiomyopathy. HCM is associated with heart failure (HF), arrhythmia, and acute coronary syndrome (ACS). The influence of sex on in-hospital outcomes in HCM is unknown. We conducted a nationwide analysis to compare outcomes between women and men with HCM hospitalized for HF, arrhythmias, or ACS.

Methods

This retrospective cohort analysis of the 2022 National Inpatient Sample (NIS) identified adults hospitalized with acute HF, arrhythmia, or ACS plus a secondary diagnosis of HCM. The primary outcome was in-hospital mortality. Secondary outcomes included length of stay (LOS) and total hospital charges. Multivariable logistic and linear regression models were used to adjust for demographics and comorbidities.

Results

Among 5,089 HCM admissions (51.1 % female; mean age 65.9 years), women were older (68.9 vs. 62.1 years) and more often admitted for acute HF. Arrhythmia presentations were similarly common in both sexes, and men more frequently had ACS. In-hospital mortality was 1.7 % and did not differ by sex after adjustment (adjusted odds ratio 1.3, p = 0.63). Mean LOS was 4.3 days and was similar between sexes. Total hospitalization charges showed no significant sex difference for HF or ACS, but men incurred higher charges for arrhythmias.

Conclusions

In this nationwide analysis, sex was not an independent predictor of in-hospital mortality or LOS among admissions with HCM and acute cardiovascular events. Resource utilization was broadly comparable except for arrhythmia admissions, where charges were substantially higher in men. Differences in hospital charges suggest that differences in management may exist.

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肥厚性心肌病住院结果的性别差异：一项全国性分析

背景：肥厚性心肌病（HCM）是最常见的遗传性心肌病。HCM与心力衰竭（HF）、心律失常和急性冠状动脉综合征（ACS）有关。性别对HCM患者住院结果的影响尚不清楚。我们进行了一项全国性的分析，比较因HF、心律失常或ACS住院的HCM患者的男女预后。方法：对2022年全国住院患者样本（NIS）进行回顾性队列分析，确定了急性心衰、心律失常或ACS合并HCM的住院成年人。主要终点是住院死亡率。次要结局包括住院时间（LOS）和总住院费用。使用多变量logistic和线性回归模型来调整人口统计学和合并症。结果：在5089例HCM入院患者中（51.1%为女性，平均年龄65.9岁），女性年龄较大（68.9岁对62.1岁），且更常因急性心衰入院。心律失常的表现在两性中同样常见，男性更常患有ACS。住院死亡率为1.7%，校正后性别差异无统计学意义（校正优势比为1.3,p=0.63）。平均生存期为4.3天，两性之间相似。HF和ACS的总住院费用无显著性差异，但男性因心律失常的住院费用较高。结论：在这项全国性的分析中，性别不是HCM和急性心血管事件入院患者的住院死亡率或LOS的独立预测因子。除了心律失常入院外，资源利用率大致相当，其中男性收费高得多。医院收费的差异表明可能存在管理上的差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Problems in Cardiology 医学-心血管系统

CiteScore

4.80

自引率

2.40%

发文量

392

审稿时长

6 days

期刊介绍： Under the editorial leadership of noted cardiologist Dr. Hector O. Ventura, Current Problems in Cardiology provides focused, comprehensive coverage of important clinical topics in cardiology. Each monthly issues, addresses a selected clinical problem or condition, including pathophysiology, invasive and noninvasive diagnosis, drug therapy, surgical management, and rehabilitation; or explores the clinical applications of a diagnostic modality or a particular category of drugs. Critical commentary from the distinguished editorial board accompanies each monograph, providing readers with additional insights. An extensive bibliography in each issue saves hours of library research.