Preliminary insights on the daily rhythm of CRP and IL-6 in athletic horses

IF 1.6 3区农林科学 Q2 VETERINARY SCIENCES

Journal of Equine Veterinary Science Pub Date : 2025-09-10 DOI:10.1016/j.jevs.2025.105702

F. Aragona , M. Rizzo , F. Arfuso , F. Arrigo , F. Fazio , E. Giudice , C. Faggio , G. Piccione , C. Giannetto

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Abstract

Background

Homeostasis and inflammation are two opposing physiological processes that are driven by the circadian clock.

Aims/objectives

The study aim was to investigate the biological rhythm of the C-reactive protein (CRP) and Interleukin-6 (IL-6) in horses.

Methods

Eight clinically healthy Italian saddle gelding horses, housed in individual boxes and subjected to a natural 12/12 L/D cycle, were enrolled. Blood samples were performed every 4 hours over a 48-hour period.

Results

A positive correlation was found between CRP and IL-6 on both days of monitoring. Both parameters showed a daily rhythm; CRP acrophase was in the middle of the scotophase, IL-6 acrophase at the beginning of the light phase, and both parameters had a high percentage of robustness (>75%).

Conclusion

This preliminary information improves the knowledge about the daily rhythm and possible correlation of some inflammatory biomarkers in horses. Further studies are necessary to investigate how different environmental conditions, management, and physical exercise might influence this rhythmicity.

查看原文本刊更多论文

对运动马CRP和IL-6日常节律的初步认识。

背景：体内平衡和炎症是由生物钟驱动的两个相反的生理过程。目的：研究马体内c反应蛋白（CRP）和白细胞介素-6 （IL-6）的生物节律。方法：选取8匹临床健康的意大利马鞍骟马，分别饲养于单独的马箱内，进行自然的12/12 L/D循环。在48小时内每4小时采集一次血样。结果：CRP与IL-6在监测的2天均呈正相关。这两个参数都显示出每日节律；CRP顶相在暗相中期，IL-6顶相在光相开始，两个参数的稳健性百分比都很高（>75%）。结论：这一初步信息提高了对马的日常节律和一些炎症生物标志物可能的相关性的认识。需要进一步研究不同的环境条件、管理和体育锻炼如何影响这种节律性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Equine Veterinary Science 农林科学-兽医学

CiteScore

2.70

自引率

7.70%

发文量

249

审稿时长

77 days

期刊介绍： Journal of Equine Veterinary Science (JEVS) is an international publication designed for the practicing equine veterinarian, equine researcher, and other equine health care specialist. Published monthly, each issue of JEVS includes original research, reviews, case reports, short communications, and clinical techniques from leaders in the equine veterinary field, covering such topics as laminitis, reproduction, infectious disease, parasitology, behavior, podology, internal medicine, surgery and nutrition.