Precision medicine in liver transplantation for hepatocellular carcinoma: applications and prospects of third-generation sequencing technology.

IF 2.8 3区 医学 Q3 ONCOLOGY
Ye Tian, Xiaojuan Wang, Qian Lu
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引用次数: 0

Abstract

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide. Liver transplantation (LT) remains a vital treatment for HCC, yet it still faces numerous challenges in patient selection, recurrence monitoring, and personalized therapy. Third-generation sequencing (TGS), with its advantages of long read length, high throughput, direct detection of epigenetic modifications, real-time analysis and high accuracy, offers promise for advancing precision medicine in LT. While previous reviews have focused on TGS technical features, this review uniquely synthesizes its role in addressing specific clinical challenges in LT-HCC management and critically assesses its translational pathway. Specifically, it systematically examines TGS applications in candidate screening, recurrence monitoring, and personalized therapy for LT-HCC, analyzes its prospects for clinical translation, and aims to provide new insights for precise HCC treatment. We also discuss barriers to implementation and suggest solutions for integrating TGS into clinical workflows. This review provides a roadmap for leveraging TGS to revolutionize precision medicine in transplant hepatology.

Abstract Image

Abstract Image

精准医学在肝癌肝移植中的应用:第三代测序技术的应用与展望
肝细胞癌(HCC)是全球癌症相关死亡的主要原因之一。肝移植(LT)仍然是HCC的重要治疗方法,但在患者选择、复发监测和个性化治疗方面仍面临许多挑战。第三代测序(TGS)以其长读取长度、高通量、直接检测表观遗传修饰、实时分析和高精度的优势,为推进lt精准医疗提供了希望。以往的综述主要集中在TGS的技术特点上,本综述独特地综合了其在解决LT-HCC治疗中特定临床挑战中的作用,并批判性地评估了其转化途径。具体而言,系统探讨TGS在LT-HCC候选筛查、复发监测和个性化治疗中的应用,分析其临床转化前景,旨在为HCC的精准治疗提供新的见解。我们还讨论了实施的障碍,并提出了将TGS整合到临床工作流程中的解决方案。这篇综述为利用TGS革新移植肝病学的精准医学提供了一个路线图。
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来源期刊
CiteScore
4.00
自引率
2.80%
发文量
577
审稿时长
2 months
期刊介绍: The "Journal of Cancer Research and Clinical Oncology" publishes significant and up-to-date articles within the fields of experimental and clinical oncology. The journal, which is chiefly devoted to Original papers, also includes Reviews as well as Editorials and Guest editorials on current, controversial topics. The section Letters to the editors provides a forum for a rapid exchange of comments and information concerning previously published papers and topics of current interest. Meeting reports provide current information on the latest results presented at important congresses. The following fields are covered: carcinogenesis - etiology, mechanisms; molecular biology; recent developments in tumor therapy; general diagnosis; laboratory diagnosis; diagnostic and experimental pathology; oncologic surgery; and epidemiology.
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