Tailoring polyethersulfone membranes with polycitrate for controlled transdermal delivery of azithromycin to enhance therapeutic potential

IF 4.7 3区医学 Q1 PHARMACOLOGY & PHARMACY

European Journal of Pharmaceutical Sciences Pub Date : 2025-09-10 DOI:10.1016/j.ejps.2025.107263

Mahya Samari , Soheila Kashanian , Sirus Zinadini , Hossein Derakhshankhah

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引用次数: 0

Abstract

This study explores the development and application of polycitrate-modified membranes for controlled drug delivery. The synthesis of polycitrate was achieved through the self-condensation of citric acid, confirmed by FT-IR spectroscopy, which indicated successful polymerization. Scanning electron microscopy revealed a two-layered membrane structure with a dense top-layer and porous sub-layers. The incorporation of polycitrate increased porosity (from 39.48 % to 64.81 %) and hydrophilicity, enhancing pore formation and drug release. Membranes with 1.5 wt. % polycitrate (M4) showed the best performance, achieving a release of 455 mg/L of azithromycin, with a zero-order release mechanism ensuring a steady rate. The optimal membrane thickness for drug release efficiency was found to be 300 µm, effectively balancing storage capacity with release characteristics. Evaluations confirmed the membranes' reusability and stability through 10 cyclic loading and sterilization processes. The increased water vapor transmission rates indicated their suitability as wound dressings, promoting an optimal healing environment. Additionally, improvements in tensile strength and controlled degradation highlight the potential of these membranes for advanced drug delivery systems. Overall, polycitrate-modified membranes emerge as a promising solution for transdermal drug delivery in clinical applications.

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剪裁聚柠檬酸聚醚砜膜控制阿奇霉素的透皮输送，以提高治疗潜力。

本研究探讨了聚柠檬酸盐修饰膜的开发与应用。通过柠檬酸的自缩合反应合成了聚柠檬酸盐，并通过红外光谱证实了聚合反应的成功。扫描电镜显示了双层膜结构，表层致密，亚层多孔。多柠檬酸盐的掺入增加了孔隙度（从39.48%增加到64.81%）和亲水性，促进了孔隙的形成和药物的释放。含1.5 wt. %多柠檬酸盐（M4）的膜表现最佳，阿奇霉素的释放量为455 mg/L，且为零级释放机制，保证了稳定的释放速率。药物释放效率的最佳膜厚度为300µm，有效地平衡了储存容量和释放特性。通过10次循环加载和灭菌过程，评价证实了膜的可重复使用性和稳定性。水蒸气透过率的增加表明其适合作为伤口敷料，促进最佳愈合环境。此外，在拉伸强度和控制降解方面的改进突出了这些膜在先进药物输送系统中的潜力。总之，在临床应用中，聚柠檬酸盐修饰膜是一种很有前途的经皮给药解决方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Pharmaceutical Sciences 医学-药学

CiteScore

9.60

自引率

2.20%

发文量

248

审稿时长

50 days

期刊介绍： The journal publishes research articles, review articles and scientific commentaries on all aspects of the pharmaceutical sciences with emphasis on conceptual novelty and scientific quality. The Editors welcome articles in this multidisciplinary field, with a focus on topics relevant for drug discovery and development. More specifically, the Journal publishes reports on medicinal chemistry, pharmacology, drug absorption and metabolism, pharmacokinetics and pharmacodynamics, pharmaceutical and biomedical analysis, drug delivery (including gene delivery), drug targeting, pharmaceutical technology, pharmaceutical biotechnology and clinical drug evaluation. The journal will typically not give priority to manuscripts focusing primarily on organic synthesis, natural products, adaptation of analytical approaches, or discussions pertaining to drug policy making. Scientific commentaries and review articles are generally by invitation only or by consent of the Editors. Proceedings of scientific meetings may be published as special issues or supplements to the Journal.