Cardiac Development, Cellular Composition and Function: From Regulatory Mechanisms to Applications.

IF 5.2 2区生物学 Q2 CELL BIOLOGY

Cells Pub Date : 2025-09-05 DOI:10.3390/cells14171390

Huan-Yu Zhao, Jie-Bing Jiang, Shu-Na Wang, Chao-Yu Miao

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Abstract

Cardiogenesis and heart cell composition and function constitute fundamental areas of cardiovascular medicine research, and exploring their underlying mechanisms is closely tied to the goals of precision medicine. This review comprehensively examines the composition and functions of the heart from embryonic organogenesis to maturity, and highlights the main breakthroughs of treatment strategies associated with these processes. By elaborating on the spatiotemporally specific signaling pathways and transcriptional networks that drive heart organogenesis and progenitor cell fate determination during the pivotal stages of cardiac development, and by systematically presenting the molecular biomarkers and functional characteristics of the principal cell types in mature heart, the latest advancements in related applications are summarized, with a particular emphasis on breakthroughs in gene/cell therapy, organoid development, and tissue engineering and regenerative medicine. This paper provides a theoretical foundation for precision interventions and regenerative medicine in cardiovascular disease using an axis that integrates cardiogenesis, cellular architecture, and therapeutic translation.

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心脏发育、细胞组成和功能：从调控机制到应用。

心脏发生和心脏细胞组成和功能是心血管医学研究的基础领域，探索其潜在机制与精准医学的目标密切相关。本文综述了心脏从胚胎器官发生到成熟的组成和功能，并重点介绍了与这些过程相关的治疗策略的主要突破。通过阐述心脏发育关键阶段驱动心脏器官发生和祖细胞命运决定的时空特异性信号通路和转录网络，并系统介绍成熟心脏主要细胞类型的分子生物标志物和功能特征，总结了相关应用的最新进展，重点介绍了基因/细胞治疗方面的突破。类器官发育，组织工程和再生医学。本文为心血管疾病的精确干预和再生医学提供了一个理论基础，利用一个整合心脏发生、细胞结构和治疗翻译的轴。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cells Biochemistry, Genetics and Molecular Biology-Biochemistry, Genetics and Molecular Biology (all)

CiteScore

9.90

自引率

5.00%

发文量

3472

审稿时长

16 days

期刊介绍： Cells (ISSN 2073-4409) is an international, peer-reviewed open access journal which provides an advanced forum for studies related to cell biology, molecular biology and biophysics. It publishes reviews, research articles, communications and technical notes. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. There is no restriction on the length of the papers. Full experimental and/or methodical details must be provided.