A Robust Nanocatalyst Incorporating Multi-Walled Carbon Nanotubes Infused with Magnetic Nanoparticles and Biguanide-Silver Nanoparticles for Multicomponent Synthesis of Benzopyrano-Pyrimidines.

IF 3.1 4区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
Anwer Ali Mueen, Suranjana V Mayani, Suhas Ballal, Shaker Al-Hasnaawei, Abhayveer Singh, Kattela Chennakesavulu, Kamal Kant Joshi, Reza Mohammadi
{"title":"A Robust Nanocatalyst Incorporating Multi-Walled Carbon Nanotubes Infused with Magnetic Nanoparticles and Biguanide-Silver Nanoparticles for Multicomponent Synthesis of Benzopyrano-Pyrimidines.","authors":"Anwer Ali Mueen, Suranjana V Mayani, Suhas Ballal, Shaker Al-Hasnaawei, Abhayveer Singh, Kattela Chennakesavulu, Kamal Kant Joshi, Reza Mohammadi","doi":"10.1002/open.202500398","DOIUrl":null,"url":null,"abstract":"<p><p>A highly efficient and environmentally friendly synthetic method has been developed for the preparation of benzopyrano-pyrimidines using multi-walled carbon nanotubes/magnetic nanoparticles-Biguanide-Ag NPs as a heterogeneous nanocatalyst in choline chloride-urea (ChCl-Urea) deep eutectic solvent. This approach offers numerous advantages, including high isolated yields (86-99%) and short reaction times (10-70 min), along with broad substrate compatibility for both electron-donating and electron-withdrawing functional groups. The method exhibits excellent catalytic efficiency, with high turnover numbers and turnover frequencies, even at low catalyst loading. The use of ChCl-Urea as a green, biodegradable, and nonvolatile solvent aligns with sustainable chemistry principles and allows for easy solvent recovery. Additionally, the magnetic nanocatalyst is easily recoverable and reusable, maintaining activity over multiple cycles. Operational simplicity, mild conditions, and one-pot multi-component reaction design further enhance the method's scalability and synthetic utility. Given the biological relevance of benzopyrano-pyrimidines, this strategy presents a valuable platform for green synthesis in medicinal chemistry and pharmaceutical development.</p>","PeriodicalId":9831,"journal":{"name":"ChemistryOpen","volume":" ","pages":"e202500398"},"PeriodicalIF":3.1000,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemistryOpen","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1002/open.202500398","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0

Abstract

A highly efficient and environmentally friendly synthetic method has been developed for the preparation of benzopyrano-pyrimidines using multi-walled carbon nanotubes/magnetic nanoparticles-Biguanide-Ag NPs as a heterogeneous nanocatalyst in choline chloride-urea (ChCl-Urea) deep eutectic solvent. This approach offers numerous advantages, including high isolated yields (86-99%) and short reaction times (10-70 min), along with broad substrate compatibility for both electron-donating and electron-withdrawing functional groups. The method exhibits excellent catalytic efficiency, with high turnover numbers and turnover frequencies, even at low catalyst loading. The use of ChCl-Urea as a green, biodegradable, and nonvolatile solvent aligns with sustainable chemistry principles and allows for easy solvent recovery. Additionally, the magnetic nanocatalyst is easily recoverable and reusable, maintaining activity over multiple cycles. Operational simplicity, mild conditions, and one-pot multi-component reaction design further enhance the method's scalability and synthetic utility. Given the biological relevance of benzopyrano-pyrimidines, this strategy presents a valuable platform for green synthesis in medicinal chemistry and pharmaceutical development.

多壁碳纳米管注入磁性纳米粒子和双胍银纳米粒子用于多组分合成苯并吡喃-嘧啶。
在氯化胆碱-尿素(chcl -尿素)深度共熔溶剂中,以多壁碳纳米管/磁性纳米颗粒-双胍-银纳米粒子为非均相纳米催化剂,制备了一种高效环保的苯并吡喃嘧啶合成方法。该方法具有许多优点,包括高分离收率(86-99%)和短反应时间(10-70分钟),以及对供电子和吸电子官能团的广泛底物兼容性。该方法表现出优异的催化效率,即使在低催化剂负载下也具有较高的周转次数和周转频率。氯化脲作为一种绿色的、可生物降解的、不挥发的溶剂,符合可持续化学原理,并且易于溶剂回收。此外,磁性纳米催化剂易于回收和重复使用,在多个循环中保持活性。操作简单,条件温和,一锅多组分反应设计进一步提高了该方法的可扩展性和合成实用性。鉴于苯并吡喃嘧啶的生物学相关性,该策略为药物化学和药物开发中的绿色合成提供了一个有价值的平台。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
ChemistryOpen
ChemistryOpen CHEMISTRY, MULTIDISCIPLINARY-
CiteScore
4.80
自引率
4.30%
发文量
143
审稿时长
1 months
期刊介绍: ChemistryOpen is a multidisciplinary, gold-road open-access, international forum for the publication of outstanding Reviews, Full Papers, and Communications from all areas of chemistry and related fields. It is co-owned by 16 continental European Chemical Societies, who have banded together in the alliance called ChemPubSoc Europe for the purpose of publishing high-quality journals in the field of chemistry and its border disciplines. As some of the governments of the countries represented in ChemPubSoc Europe have strongly recommended that the research conducted with their funding is freely accessible for all readers (Open Access), ChemPubSoc Europe was concerned that no journal for which the ethical standards were monitored by a chemical society was available for such papers. ChemistryOpen fills this gap.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信