Octylisothiazolinone-A New Sensitizer in Over-Ear Headphones.

IF 4.6 1区医学 Q2 ALLERGY

Contact Dermatitis Pub Date : 2025-09-13 DOI:10.1111/cod.70028

Blerand Berisha, Tina Lejding, Ola Bergendorff, Inese Hauksson

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引用次数: 0

Abstract

Background: Allergic contact dermatitis (ACD) caused by isothiazolinones is a growing concern, particularly in consumer products. Octylisothiazolinone (OIT) is a potent sensitiser and commonly used as a preservative in rubbers, plastics and coatings, including those found in headphones. Despite increasing regulations on isothiazolinones in cosmetics, their presence in wearable devices remains under-recognised.

Aims: This investigation aims to identify OIT as a possible sensitiser in patients with presumed ACD due to over-ear headphones.

Methods: Two patients with presumed ACD due to over-ear headphones were patch tested at the Department of Occupational and Environmental Dermatology, Skåne University Hospital, Malmö. Patch testing included Swedish baseline series, isothiazolinone compounds, and materials from headphones. To identify potential allergens, chemical analysis of components from headphones was conducted using high-performance liquid chromatography (HPLC).

Results: Patch testing demonstrated strong positive reactions to OIT in both cases, with additional reactions to acetone extracts of artificial leather and blue plastic foam. OIT remained positive at dilutions as low as 0.00003%. Case 1 also showed positive reactions to MI/MCI. Chemical analysis confirmed OIT in both artificial leather (2.2 mg/g) and plastic foam (0.3 mg/g).

Conclusions: These findings contribute to the understanding of ACD by identifying OIT as a potential allergen in over-ear headphones. It calls for further research into the prevalence of OIT in consumer electronics and its role in sensitisation.

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一种新型耳戴式耳机增敏剂——辛基异噻唑啉酮。

背景：异噻唑啉酮引起的过敏性接触性皮炎（ACD）日益受到关注，特别是在消费品中。辛基利异噻唑啉酮（OIT）是一种强效致敏剂，通常用作橡胶、塑料和涂料的防腐剂，包括耳机中的防腐剂。尽管化妆品中的异噻唑啉酮法规越来越多，但它们在可穿戴设备中的存在仍未得到充分认识。目的：本研究的目的是确定OIT作为一个可能的致敏物，在患者推定的ACD由于戴耳式耳机。方法：在sk大学医院职业与环境皮肤科（Malmö）对2例推测为耳罩式耳机引起的ACD患者进行了贴片试验。贴片测试包括瑞典基线系列、异噻唑啉酮化合物和耳机材料。为了鉴定潜在的过敏原，采用高效液相色谱法对耳机成分进行化学分析。结果：斑贴试验表明，在这两种情况下，对OIT有强烈的积极反应，对人造皮革和蓝色塑料泡沫的丙酮提取物有额外的反应。在低至0.00003%的稀释度下，OIT仍为正。病例1也显示MI/MCI阳性反应。化学分析证实，人造皮革（2.2 mg/g）和塑料泡沫（0.3 mg/g）中都含有油脂。结论：这些发现有助于通过确定OIT作为耳罩式耳机中的潜在过敏原来理解ACD。它呼吁进一步研究OIT在消费电子产品中的流行程度及其在致敏中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Contact Dermatitis 医学-过敏

CiteScore

4.60

自引率

30.90%

发文量

227

审稿时长

4-8 weeks

期刊介绍： Contact Dermatitis is designed primarily as a journal for clinicians who are interested in various aspects of environmental dermatitis. This includes both allergic and irritant (toxic) types of contact dermatitis, occupational (industrial) dermatitis and consumers" dermatitis from such products as cosmetics and toiletries. The journal aims at promoting and maintaining communication among dermatologists, industrial physicians, allergists and clinical immunologists, as well as chemists and research workers involved in industry and the production of consumer goods. Papers are invited on clinical observations, diagnosis and methods of investigation of patients, therapeutic measures, organisation and legislation relating to the control of occupational and consumers".