Pip-SW: Pipeline Architectures for Accelerating Smith-Waterman Algorithm on FPGA Platforms

IF 5.4 2区 计算机科学 Q1 COMPUTER SCIENCE, INFORMATION SYSTEMS
Mahmood Kalemati;Ali Dehghan Nayeri;Somayyeh Koohi
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引用次数: 0

Abstract

The Smith-Waterman algorithm, which is founded on a dynamic programming approach, serves as a precise tool for aligning biological sequences. Despite its utility, the algorithm grapples with computational complexity and resource demands. Various implementations across multi-core, GPU, and FPGA platforms have sought to expedite the algorithm, yet frequently encounter issues such as suboptimal speedup, heightened reliance on external memory resources, and an exclusive focus on the forward step of the algorithm. To tackle these challenges, this study introduces an architecture aimed at accelerating the Smith-Waterman algorithm on FPGA platforms. Our architecture capitalizes on a pipeline structure that integrates optimized circuitry for parallel computations and employs memory allocation techniques, thus delivering an efficient, low power and cost-effective implementation for biological sequence alignment. Our assessments, coupled with comparisons against alternative FPGA implementations supporting protein sequence alignment, reveal a 17% increase in operating frequency and a 17% enhancement in Giga cell updates per second. Moreover, our approach competes with GPU-based solutions, showcasing comparable performance metrics alongside superior energy efficiency, with a 35% improvement. We substantiate the utility and performance of our pipeline architecture on FPGA platforms using four benchmark datasets. The validation results demonstrate a speedup ranging from 10 to 45 times for alignment score computation compared to the CPU platform.
Pip-SW: FPGA平台上加速Smith-Waterman算法的流水线架构
史密斯-沃特曼算法建立在动态规划方法的基础上,是一种精确的生物序列比对工具。尽管它很实用,但该算法与计算复杂性和资源需求有关。跨多核、GPU和FPGA平台的各种实现都试图加快算法的速度,但经常遇到诸如次优加速、对外部内存资源的高度依赖以及只关注算法的前进步骤等问题。为了应对这些挑战,本研究引入了一种旨在加速FPGA平台上Smith-Waterman算法的架构。我们的架构利用管道结构,集成了并行计算的优化电路,并采用内存分配技术,从而为生物序列比对提供高效,低功耗和经济高效的实现。我们的评估,再加上与支持蛋白质序列比对的其他FPGA实现的比较,显示工作频率提高了17%,每秒千兆细胞更新速度提高了17%。此外,我们的方法与基于gpu的解决方案竞争,展示了可比的性能指标和卓越的能源效率,提高了35%。我们使用四个基准数据集在FPGA平台上证实了我们的管道架构的实用性和性能。验证结果表明,与CPU平台相比,校准分数计算的速度提高了10到45倍。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
IEEE Transactions on Emerging Topics in Computing
IEEE Transactions on Emerging Topics in Computing Computer Science-Computer Science (miscellaneous)
CiteScore
12.10
自引率
5.10%
发文量
113
期刊介绍: IEEE Transactions on Emerging Topics in Computing publishes papers on emerging aspects of computer science, computing technology, and computing applications not currently covered by other IEEE Computer Society Transactions. Some examples of emerging topics in computing include: IT for Green, Synthetic and organic computing structures and systems, Advanced analytics, Social/occupational computing, Location-based/client computer systems, Morphic computer design, Electronic game systems, & Health-care IT.
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