{"title":"Pip-SW: Pipeline Architectures for Accelerating Smith-Waterman Algorithm on FPGA Platforms","authors":"Mahmood Kalemati;Ali Dehghan Nayeri;Somayyeh Koohi","doi":"10.1109/TETC.2024.3472649","DOIUrl":null,"url":null,"abstract":"The Smith-Waterman algorithm, which is founded on a dynamic programming approach, serves as a precise tool for aligning biological sequences. Despite its utility, the algorithm grapples with computational complexity and resource demands. Various implementations across multi-core, GPU, and FPGA platforms have sought to expedite the algorithm, yet frequently encounter issues such as suboptimal speedup, heightened reliance on external memory resources, and an exclusive focus on the forward step of the algorithm. To tackle these challenges, this study introduces an architecture aimed at accelerating the Smith-Waterman algorithm on FPGA platforms. Our architecture capitalizes on a pipeline structure that integrates optimized circuitry for parallel computations and employs memory allocation techniques, thus delivering an efficient, low power and cost-effective implementation for biological sequence alignment. Our assessments, coupled with comparisons against alternative FPGA implementations supporting protein sequence alignment, reveal a 17% increase in operating frequency and a 17% enhancement in Giga cell updates per second. Moreover, our approach competes with GPU-based solutions, showcasing comparable performance metrics alongside superior energy efficiency, with a 35% improvement. We substantiate the utility and performance of our pipeline architecture on FPGA platforms using four benchmark datasets. The validation results demonstrate a speedup ranging from 10 to 45 times for alignment score computation compared to the CPU platform.","PeriodicalId":13156,"journal":{"name":"IEEE Transactions on Emerging Topics in Computing","volume":"13 3","pages":"628-639"},"PeriodicalIF":5.4000,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"IEEE Transactions on Emerging Topics in Computing","FirstCategoryId":"94","ListUrlMain":"https://ieeexplore.ieee.org/document/10715488/","RegionNum":2,"RegionCategory":"计算机科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"COMPUTER SCIENCE, INFORMATION SYSTEMS","Score":null,"Total":0}
引用次数: 0
Abstract
The Smith-Waterman algorithm, which is founded on a dynamic programming approach, serves as a precise tool for aligning biological sequences. Despite its utility, the algorithm grapples with computational complexity and resource demands. Various implementations across multi-core, GPU, and FPGA platforms have sought to expedite the algorithm, yet frequently encounter issues such as suboptimal speedup, heightened reliance on external memory resources, and an exclusive focus on the forward step of the algorithm. To tackle these challenges, this study introduces an architecture aimed at accelerating the Smith-Waterman algorithm on FPGA platforms. Our architecture capitalizes on a pipeline structure that integrates optimized circuitry for parallel computations and employs memory allocation techniques, thus delivering an efficient, low power and cost-effective implementation for biological sequence alignment. Our assessments, coupled with comparisons against alternative FPGA implementations supporting protein sequence alignment, reveal a 17% increase in operating frequency and a 17% enhancement in Giga cell updates per second. Moreover, our approach competes with GPU-based solutions, showcasing comparable performance metrics alongside superior energy efficiency, with a 35% improvement. We substantiate the utility and performance of our pipeline architecture on FPGA platforms using four benchmark datasets. The validation results demonstrate a speedup ranging from 10 to 45 times for alignment score computation compared to the CPU platform.
期刊介绍:
IEEE Transactions on Emerging Topics in Computing publishes papers on emerging aspects of computer science, computing technology, and computing applications not currently covered by other IEEE Computer Society Transactions. Some examples of emerging topics in computing include: IT for Green, Synthetic and organic computing structures and systems, Advanced analytics, Social/occupational computing, Location-based/client computer systems, Morphic computer design, Electronic game systems, & Health-care IT.