Influence of microbiota composition on the pathogenesis of type 2 diabetes: Physiological aspects

IF 10.3 2区医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Molecular Aspects of Medicine Pub Date : 2025-09-13 DOI:10.1016/j.mam.2025.101410

Nataliya V. Zharova , Filipp D. Mikhailidi , Darya A. Kabanova , Alena Y. Tatarintseva , Olga L. Polyakova , Yury O. Zharikov , Nikolai A. Zharov , Sergey N. Ryagin , André Pontes-Silva , Tatiana S. Zharikova

引用次数: 0

Abstract

The development of type 2 diabetes may be influenced by enterotypes and bacterial metabolites. The most important of these are short-chain fatty acids (SCFAs), which play a role in forming the gut-brain axis and in the process of lipogenesis. An increase in lipogenesis can lead to obesity. High levels of adipose tissue in the body trigger chronic inflammation and insulin resistance. This review examines how microbiota composition influences the pathogenesis of type 2 diabetes and the possibility of regulating microbiota through proper nutrition, fecal microbiota transplantation, and prebiotics and probiotics. Additionally, the review notes that an imbalance in the gut microbiota can contribute to diabetes progression and increase cancer risk through inflammatory and immune mechanisms.

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微生物群组成对2型糖尿病发病机制的影响：生理方面

2型糖尿病的发展可能受到肠道类型和细菌代谢物的影响。其中最重要的是短链脂肪酸（SCFAs），它在肠-脑轴的形成和脂肪生成过程中发挥作用。脂肪生成的增加会导致肥胖。体内高水平的脂肪组织会引发慢性炎症和胰岛素抵抗。本文综述了微生物群组成如何影响2型糖尿病的发病机制，以及通过适当的营养、粪便微生物群移植、益生元和益生菌来调节微生物群的可能性。此外，该综述指出，肠道微生物群的不平衡可以通过炎症和免疫机制促进糖尿病的进展并增加癌症风险。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Aspects of Medicine 医学-生化与分子生物学

CiteScore

18.20

自引率

0.00%

发文量

审稿时长

55 days

期刊介绍： Molecular Aspects of Medicine is a review journal that serves as an official publication of the International Union of Biochemistry and Molecular Biology. It caters to physicians and biomedical scientists and aims to bridge the gap between these two fields. The journal encourages practicing clinical scientists to contribute by providing extended reviews on the molecular aspects of a specific medical field. These articles are written in a way that appeals to both doctors who may struggle with basic science and basic scientists who may have limited awareness of clinical practice issues. The journal covers a wide range of medical topics to showcase the molecular insights gained from basic science and highlight the challenging problems that medicine presents to the scientific community.