Deep eutectic solvent nanoparticles for enhanced hyaluronic acid intradermal delivery: Anti-aging and moisturizing effects

IF 2.9 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY

Materialia Pub Date : 2025-09-07 DOI:10.1016/j.mtla.2025.102548

Bo Yang , Shuang Liang , Hongtao Han , Yuesheng Majia , Jiaheng Zhang , Gang Zhao , Chengyu Wu

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Abstract

To address the challenge of poor intradermal penetration of hyaluronic acid (HA), researchers applied deep eutectic solvent (DES) technology within a drug delivery system. In this study, supramolecular HA nanoparticles (Supra HA) were successfully prepared by combining HA and decanoic acid-menthol deep eutectic solvent (DAM-DES). The resulting Supra HA nanoparticles exhibited an average particle size of 124 nm and a zeta potential of -35 mV. The intradermal penetration efficacy of Supra HA was 2.26 times greater than that of GTCC HA. Furthermore, Supra HA significantly increased type I collagen synthesis in fibroblasts by 54.0 % and reduced MMP-1 secretion by 57.4 %, demonstrating anti-wrinkle and skin-tightening effects. Under identical conditions, Supra HA enhanced the synthesis of the FLG gene and AQP3 protein in keratinocytes by 55 % and 227.4 %, respectively, indicating skin barrier repair and moisturizing effects. Human clinical trials demonstrated that 28-day application of Supra HA significantly enhanced skin hydration (13.3 % increace), with concurrent improvements in skin elasticity (21.3 % increase), firmness (21.9 % elevation), and wrinkle reduction (20.1 % decrease in count and 23.3 % reduction in area). Collectively, these findings indicate that the utilization of deep eutectic solvents in hyaluronic acid delivery systems facilitates transdermal permeation, thereby contributing to sustained moisturization and anti-aging efficacy.

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深层共熔溶剂纳米颗粒，增强透明质酸皮内输送：抗衰老和保湿效果

为了解决透明质酸（HA）皮内渗透性差的问题，研究人员在给药系统中应用了深共熔溶剂（DES）技术。本研究将透明质酸与癸酸-薄荷醇深度共熔溶剂（DAM-DES）结合，成功制备了超分子透明质酸纳米粒子（Supra HA）。所得的Supra HA纳米颗粒平均粒径为124 nm， zeta电位为-35 mV。Supra HA的皮内渗透效能是GTCC HA的2.26倍。此外，Supra HA显著增加了成纤维细胞中I型胶原合成54.0%，减少了57.4%的MMP-1分泌，具有抗皱和紧肤作用。在相同条件下，Supra HA可使角质形成细胞中FLG基因和AQP3蛋白的合成分别提高55%和227.4%，具有皮肤屏障修复和保湿作用。人体临床试验表明，使用28天Supra HA可显著增强皮肤水合作用（增加13.3%），同时改善皮肤弹性（增加21.3%），紧致度（增加21.9%），减少皱纹（减少20.1%，减少23.3%）。总的来说，这些发现表明，在透明质酸输送系统中使用深层共晶溶剂有助于透皮渗透，从而有助于持续保湿和抗衰老功效。

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来源期刊

Materialia MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

6.40

自引率

2.90%

发文量

345

审稿时长

36 days

期刊介绍： Materialia is a multidisciplinary journal of materials science and engineering that publishes original peer-reviewed research articles. Articles in Materialia advance the understanding of the relationship between processing, structure, property, and function of materials. Materialia publishes full-length research articles, review articles, and letters (short communications). In addition to receiving direct submissions, Materialia also accepts transfers from Acta Materialia, Inc. partner journals. Materialia offers authors the choice to publish on an open access model (with author fee), or on a subscription model (with no author fee).