Recyclable chitosan for copper-catalyzed Ullmann C-N coupling reaction

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2025-09-02 DOI:10.1080/00397911.2025.2548301

Yawen Hu (Conceptualization Data curation Formal analysis Investigation Methodology Writing – original draft Writing – review & editing) , Li Xu (Data curation Formal analysis) , Xue Jiang (Data curation Supervision) , Haiyang Guo (Formal analysis Investigation) , Di Wu (Conceptualization Data curation Methodology Writing – review & editing)

引用次数: 0

Abstract

A recyclable ligand chitosan was developed for the copper-catalyzed Ullmann-type cross-coupling reaction of aryl halides with amines. A variety of functionalized (hetero)aryl halides reacted smoothly with pyrazole, imidazole, aliphatic amines and ammonia to provide a wide range of (hetero)aryl amines in good to excellent yields under the catalyst of Cu₂O/chitosan system. This method has the advantages of wide substrate range, high chemoselectivity, and good functional group compatibility. The ligand is easily recycled and no significant decrease in the catalytic potency after being reused 7 times.

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可回收壳聚糖用于铜催化的Ullmann C-N偶联反应

制备了一种可回收的配体壳聚糖，用于铜催化芳基卤化物与胺的ullmann型交叉偶联反应。在Cu2O/壳聚糖体系的催化下，多种功能化（杂）芳基卤化物与吡唑、咪唑、脂肪胺和氨反应顺利，得到了多种（杂）芳基胺，收率高至优异。该方法具有底物范围广、化学选择性高、官能团相容性好等优点。该配体易于回收，重复使用7次后催化效能无明显下降。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.