Significant advances in catalytic strategies for the synthesis of trisubstituted imidazoles: a review

IF 1.8 3区化学 Q3 CHEMISTRY, ORGANIC

Synthetic Communications Pub Date : 2025-09-02 DOI:10.1080/00397911.2025.2505901

Saloni Mangal (Writing – original draft) , Salahuddin (Methodology Writing – review & editing) , Avijit Mazumder (Supervision) , Rajnish Kumar (Validation Visualization) , Sapna Rani (Data curation) , Mohamed Jawed Ahsan (Investigation) , Mohammad Shahar Yar (Conceptualization Formal analysis)

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Abstract

The catalyst plays an important role while the organic transformations are taking place. They enhance the reaction process by reducing the reaction time and provide highly efficient yields. Imidazole is one of the most common heterocyclic rings with several pharmaceutical and other significances. Trisubstituted imidazoles have various scientific and biological applications among the different types of imidazole rings. This review compiles the list of catalysts used in the synthesis of trisubstituted imidazoles using benzil, aldehydes and ammonium sources like ammonium acetate or urea. Hence, the study evaluates the efficiency of different catalytic systems in promoting the above-mentioned multicomponent reaction, leading to enhanced yields and reduced reaction times.

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三取代咪唑合成催化策略的重大进展综述

催化剂在有机转化过程中起着重要的作用。它们通过缩短反应时间来改善反应过程，并提供高效率的产率。咪唑是最常见的杂环之一，具有多种药用和其他意义。在不同类型的咪唑环中，三取代咪唑具有不同的科学和生物学应用。综述了以苯、醛、乙酸铵、尿素等铵源为原料合成三取代咪唑的催化剂。因此，本研究评估了不同催化体系在促进上述多组分反应中的效率，从而提高了产率，缩短了反应时间。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Synthetic Communications 化学-有机化学

CiteScore

4.40

自引率

4.80%

发文量

156

审稿时长

4.3 months

期刊介绍： Synthetic Communications presents communications describing new methods, reagents, and other synthetic work pertaining to organic chemistry with sufficient experimental detail to permit reported reactions to be repeated by a chemist reasonably skilled in the art. In addition, the Journal features short, focused review articles discussing topics within its remit of synthetic organic chemistry.