The various pathological roles of oxidized LDL in diseases

Q2 Medicine

Obesity Medicine Pub Date : 2025-09-01 DOI:10.1016/j.obmed.2025.100646

Abdullatif Taha Babakr

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引用次数: 0

Abstract

Oxidized low-density lipoprotein (Ox-LDL) represents a chemically altered version of low-density lipoprotein where oxidative damage modifies both its protein and lipid constituents. This oxidation can occur through direct interaction with radical molecules or via lipid peroxidation byproducts. The presence of Ox-LDL is closely associated with the development of atherosclerosis and various pathological conditions, although the precise mechanisms by which it contributes to these processes continue to be comprehensively elucidated.

The recognition of Ox-LDL marked a paradigm shift, emphasizing oxidative modification as a key driver of atherogenesis and metabolic pathologies. This discovery also encouraged the development of various biomarkers and therapeutic strategies aimed at reducing LDL oxidation as a potential way to prevent or treat cardiovascular diseases. Thus, the discovery of Ox-LDL continues to shape modern cardiovascular research and treatment approaches.

This article aims to elucidate the process of LDL oxidation and its association with various diseases. A thorough investigation was carried out across multiple databases, such as PubMed, Scopus, Google Scholar, and Ovid, to gather relevant literature and studies that explore the relationship between Ox-LDL and the pathogenesis of diseases, thereby creating a clear understanding of the topic. This review will examine the characteristics of the Ox-LDL particle, emphasizing its contributions to various pathological conditions and diseases. Finally, this review will shed light on the challenges facing the use of this biomarker in clinical practice and future recommendations.

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氧化LDL在疾病中的各种病理作用

氧化低密度脂蛋白（Ox-LDL）代表了低密度脂蛋白的化学改变版本，其中氧化损伤改变了其蛋白质和脂质成分。这种氧化可以通过与自由基分子的直接相互作用或通过脂质过氧化副产物发生。Ox-LDL的存在与动脉粥样硬化和各种病理状况的发展密切相关，尽管其促进这些过程的确切机制仍有待全面阐明。对Ox-LDL的认识标志着范式的转变，强调氧化修饰是动脉粥样硬化和代谢病理的关键驱动因素。这一发现也鼓励了各种生物标志物和治疗策略的发展，旨在减少LDL氧化，作为预防或治疗心血管疾病的潜在方法。因此，Ox-LDL的发现继续影响着现代心血管研究和治疗方法。本文旨在阐明LDL氧化过程及其与多种疾病的关系。通过对PubMed、Scopus、谷歌Scholar、Ovid等多个数据库进行深入调查，收集相关文献和研究，探讨Ox-LDL与疾病发病机制之间的关系，从而对该主题有一个清晰的认识。本文将研究Ox-LDL颗粒的特性，强调其在各种病理条件和疾病中的作用。最后，这篇综述将阐明在临床实践中使用这种生物标志物所面临的挑战和未来的建议。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Medicine Medicine-Public Health, Environmental and Occupational Health

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

40 days

期刊介绍： The official journal of the Shanghai Diabetes Institute Obesity is a disease of increasing global prevalence with serious effects on both the individual and society. Obesity Medicine focusses on health and disease, relating to the very broad spectrum of research in and impacting on humans. It is an interdisciplinary journal that addresses mechanisms of disease, epidemiology and co-morbidities. Obesity Medicine encompasses medical, societal, socioeconomic as well as preventive aspects of obesity and is aimed at researchers, practitioners and educators alike.