Measles trend in Gabon: Insight from 18 years of surveillance data

IF 4.1 2区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

iScience Pub Date : 2025-08-27 DOI:10.1016/j.isci.2025.113450

Guy Francis Nzengui Nzengui , Hervé M’boyis Kamdem , Ayawa Claudine Kombila Koumavor , Gaël Mourembou , Pélagie Mougola Bissiengou , Daniella Delpo , Rotimi Myrabelle Avome Houechenou , Fabrice Lotola Mougeni , Fortune Barondi Diambou , Annie Badila Missogni , Frédéric Ngoulou , Marcel Mouketou Mabika , Thierry Mba , Alain Mombo Mombo , Paulin Mbagou , Urlucha Marina Mbani Okoumba , Alyssa Sbarra , Saki Takahashi , Anicet Christel Maloupazoa Siawaya , Amandine Mveang Nzoghe , Angélique Ndjoyi Mbiguino

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Abstract

Measles is a vaccine-preventable infection that can lead to serious illness and death. The delayed implementation of the World Health Organization (WHO)-recommended two doses of measles-containing vaccine (MCV1 and MCV2) and immunity gaps compromise the effort to elimination. Eighteen years (2006–2023) of surveillance data from Gabon measles surveillance program were collected and analyzed. Variables included age, sex, vaccination status and date, disease date, and anti-measles immunoglobulin M (IgM) status (determined by immunoassay). The rate of infection and association studies was done. Results showed that 60.6% (1,640/2,708) of suspected cases were unvaccinated against measles. Of suspected cases, 26.1% were laboratory-confirmed cases. Unvaccinated individuals were 5.9–7.7 times more likely to be anti-measles IgM positive (p < 0.0001). Children aged ≤5 years represented 70.8% of laboratory-confirmed cases; 15.5% (30/193) of childbearing age females were confirmed cases. In Gabon, nonimmunized and underimmunized individuals are driving up measles disease and constitute a challenge to measles elimination.

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加蓬的麻疹趋势：来自18年监测数据的洞察

麻疹是一种疫苗可预防的感染，可导致严重疾病和死亡。推迟实施世界卫生组织（世卫组织）推荐的两剂含麻疹疫苗（MCV1和MCV2）以及免疫缺口妨碍了消除麻疹的努力。收集并分析了加蓬麻疹监测规划18年（2006-2023年）的监测数据。变量包括年龄、性别、疫苗接种状态和日期、发病日期和抗麻疹免疫球蛋白M （IgM）状态（通过免疫测定确定）。进行了感染率和相关性研究。结果60.6%（1640 / 2708）疑似病例未接种麻疹疫苗。在疑似病例中，26.1%为实验室确诊病例。未接种疫苗的个体抗麻疹IgM阳性的可能性高出5.9-7.7倍（p < 0.0001）。≤5岁儿童占实验室确诊病例的70.8%；育龄妇女确诊病例占15.5%（30/193）。在加蓬，未接种疫苗和免疫接种不足的个人正在推高麻疹发病率，对消除麻疹构成挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

iScience Multidisciplinary-Multidisciplinary

CiteScore

7.20

自引率

1.70%

发文量

1972

审稿时长

6 weeks

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