Biocomposite containing polyetherketoneketone and heterojunction of NaNbOX@CeO2 with improved piezoelectricity and nanozyme activity for killing bacteria and enhancing osteoblastic differentiation

IF 6 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

Materials Science & Engineering C-Materials for Biological Applications Pub Date : 2025-09-07 DOI:10.1016/j.bioadv.2025.214491

Ting Pan , Ling Li , Shipeng Wang , Shangyu Xie , Jie Wei , Lingyun Guo

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引用次数: 0

Abstract

Combination of piezoelectricity with nanozyme activity is promising strategy to develop a novel biofunctional composite for repair of infectious bone defect. Herein, a heterojunction containing oxygen vacancy sodium niobate (NaNbO_X, NO_X) with improved piezoelectricity and cerium oxide (CeO₂) with nanozyme activity (NCH) is fabricated, and a biocomposite containing polyetherketoneketone (PEKK) and NCH (PNC) is prepared, which exhibits both piezoelectricity and nanozyme activity. Under acidic condition (simulating microenvironment of bacterial infection), triggered by US, the piezoelectric effect of PNC not only remarkably improves sonodynamic efficiency for producing more reactive oxygen species (ROS), but also enhances peroxidase (POD)-like activity for generating more ROS. The US-driven piezoelectric effect of PNC significantly enhances both sonodynamic performance and enzyme-like activity that produce a large amount of ROS, synergistic killing bacteria and removing biofilms. Moreover, driven by US, the piezoelectric effect of PNC generates electrical signals, which remarkably promotes osteoblasts proliferation and osteogenic differentiation. This study opens up a new path for design a novel composite biomaterial with capability of production of ROS and pro-osteogenesis by electrical stimulation, and PNC with piezoelectricity and POD-like activity displays great potential for application in the treatment of bacterial infectious bone defects.

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含有聚醚酮酮和NaNbOX@CeO2异质结的生物复合材料，具有改善的压电性和纳米酶活性，用于杀死细菌和促进成骨细胞分化

压电性与纳米酶活性的结合是开发一种新型生物功能复合材料用于感染性骨缺损修复的有希望的策略。本文制备了具有改进压电性的氧空位铌酸钠（NaNbOX， NOX）和具有纳米酶活性（NCH）的氧化铈（CeO2）异质结，并制备了具有压电性和纳米酶活性的聚醚酮酮（PEKK）和NCH （PNC）的生物复合材料。在US触发的酸性条件下（模拟细菌感染的微环境），PNC的压电效应不仅显著提高了声动力效率以产生更多的活性氧（ROS），而且增强了过氧化物酶（POD）样活性以产生更多的ROS。PNC的us驱动压电效应显著提高了声动力性能和酶样活性，从而产生大量ROS，协同杀灭细菌和去除生物膜。此外，在US的驱动下，PNC的压电效应产生电信号，显著促进成骨细胞增殖和成骨分化。本研究为设计一种新型复合生物材料开辟了新的途径，该材料具有压电性和pod样活性，在治疗细菌感染性骨缺损方面具有很大的应用潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Materials Science & Engineering C-Materials for Biological Applications 工程技术-材料科学：生物材料

CiteScore

17.80

自引率

0.00%

发文量

501

审稿时长

27 days

期刊介绍： Biomaterials Advances, previously known as Materials Science and Engineering: C-Materials for Biological Applications (P-ISSN: 0928-4931, E-ISSN: 1873-0191). Includes topics at the interface of the biomedical sciences and materials engineering. These topics include: • Bioinspired and biomimetic materials for medical applications • Materials of biological origin for medical applications • Materials for "active" medical applications • Self-assembling and self-healing materials for medical applications • "Smart" (i.e., stimulus-response) materials for medical applications • Ceramic, metallic, polymeric, and composite materials for medical applications • Materials for in vivo sensing • Materials for in vivo imaging • Materials for delivery of pharmacologic agents and vaccines • Novel approaches for characterizing and modeling materials for medical applications Manuscripts on biological topics without a materials science component, or manuscripts on materials science without biological applications, will not be considered for publication in Materials Science and Engineering C. New submissions are first assessed for language, scope and originality (plagiarism check) and can be desk rejected before review if they need English language improvements, are out of scope or present excessive duplication with published sources. Biomaterials Advances sits within Elsevier''s biomaterials science portfolio alongside Biomaterials, Materials Today Bio and Biomaterials and Biosystems. As part of the broader Materials Today family, Biomaterials Advances offers authors rigorous peer review, rapid decisions, and high visibility. We look forward to receiving your submissions!