Sustainable watermelon rind-based bioplastic for controlled lidocaine release in topical wound dressings

IF 5.1 3区工程技术 Q1 CHEMISTRY, APPLIED

Reactive & Functional Polymers Pub Date : 2025-09-10 DOI:10.1016/j.reactfunctpolym.2025.106477

José Alberto Paris Junior , Igor Henrique Cerqueira , Nicole Pichirilli Catirse , Paula de Abreu Fernandes , Saulo Duarte Ozelin , Diógenes dos Santos Dias , Clóvis Augusto Ribeiro , Jhonatan Miguel Silva , Hernane da Silva Barud , Flávia Aparecida Resende

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Abstract

In this study, we developed and characterized biodegradable bioplastics from watermelon (Citrullus lanatus) rind, a commonly discarded agricultural byproduct, incorporating lidocaine hydrochloride (WM-LID) for potential use as functional topical wound dressings. The bioplastics exhibited favorable physicochemical and structural properties, including thermal stability, mechanical strength, and fluid handling capacity, aligning with the requirements for biomedical applications. FTIR and SEM analyses confirmed the interaction between the polymer matrix and the incorporated drug. Lidocaine release was pH-responsive, governed by the solubility of the drug and its interactions within the biopolymeric network. Biological assays revealed low cytotoxicity (2D and 3D cell models) and no genotoxic or mutagenic potential (Comet assay and Ames test), indicating a safe profile for biomedical use. The integration of a natural, renewable matrix with an active pharmaceutical ingredient demonstrates the potential of WM-LID bioplastics as sustainable and functional polymeric systems for controlled drug delivery in wound care applications.

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可持续性西瓜皮生物塑料用于控制局部伤口敷料中的利多卡因释放

在这项研究中，我们开发并表征了从西瓜（Citrullus lanatus）皮中提取的可生物降解的生物塑料，这是一种常见的废弃农业副产品，含有盐酸利多卡因（WM-LID），可用于功能性局部伤口敷料。生物塑料表现出良好的物理化学和结构性能，包括热稳定性、机械强度和流体处理能力，符合生物医学应用的要求。FTIR和SEM分析证实了聚合物基质与掺入药物之间的相互作用。利多卡因的释放是ph响应性的，受药物的溶解度及其在生物聚合物网络中的相互作用的控制。生物试验显示低细胞毒性（2D和3D细胞模型），无基因毒性或致突变潜力（Comet试验和Ames试验），表明生物医学用途的安全性。将天然可再生基质与活性药物成分相结合，证明了WM-LID生物塑料作为可持续性和功能性聚合物系统在伤口护理应用中控制药物输送的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Reactive & Functional Polymers 工程技术-高分子科学

CiteScore

8.90

自引率

5.90%

发文量

259

审稿时长

27 days

期刊介绍： Reactive & Functional Polymers provides a forum to disseminate original ideas, concepts and developments in the science and technology of polymers with functional groups, which impart specific chemical reactivity or physical, chemical, structural, biological, and pharmacological functionality. The scope covers organic polymers, acting for instance as reagents, catalysts, templates, ion-exchangers, selective sorbents, chelating or antimicrobial agents, drug carriers, sensors, membranes, and hydrogels. This also includes reactive cross-linkable prepolymers and high-performance thermosetting polymers, natural or degradable polymers, conducting polymers, and porous polymers. Original research articles must contain thorough molecular and material characterization data on synthesis of the above polymers in combination with their applications. Applications include but are not limited to catalysis, water or effluent treatment, separations and recovery, electronics and information storage, energy conversion, encapsulation, or adhesion.