pH-Sensitive acrylic acid grafted Abelmoschus esculentus composite for sustained release of pantoprazole sodium

IF 4.3 2区医学 Q1 PHARMACOLOGY & PHARMACY

European Journal of Pharmaceutics and Biopharmaceutics Pub Date : 2025-09-10 DOI:10.1016/j.ejpb.2025.114859

Maryam Basharat , Sobia Noreen , Shazia Akram Ghumman , Khadeeja Ali Alsader , Farooq Anwar , Bushra Ijaz , Tahira Batool , Fozia Batool , Afeefa Aslam , Khurram Shahzad Munawar , Samina Aslam , Nisar Ahmed

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Abstract

The research presents a pH-sensitive acrylic acid-grafted hydrogel (graft composite) derived from Abelmoschus esculentus mucilage (AEM) to improve therapeutic outcomes in Crohn’s disease and ulcerative colitis. The FT-IR spectroscopy, scanning electron microscopy (SEM), and X-ray diffraction (XRD) confirm successful grafting with a porous structure favorable for drug loading. Drug release studies showed slower PAS release under acidic conditions and faster release under alkaline conditions, mimicking the pH variations of the gastrointestinal tract. Release kinetics confirmed the Korsmeyer-Peppas model, exhibiting non-Fickian diffusion behavior, especially in the alkaline medium, with R² value ranging from 0.9874 to 0.9989. Biocompatibility assessments, including cytotoxicity, hemocompatibility, and acute oral toxicity tests, demonstrated that the graft composite is safe for use. In vivo studies confirmed an increase in the half-life of PAS from 1.119 to 4.395 h. This pH-sensitive delivery system offers a promising approach for the controlled, targeted release of PAS in the colon, enhancing therapeutic efficacy for patients with inflammatory bowel diseases. The successful development of this grafted composite represents a significant advancement in biocompatible, controlled drug delivery for gastrointestinal disorders.

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ph敏感丙烯酸接枝藻藻复合材料对泮托拉唑钠缓释的影响

该研究提出了一种来源于Abelmoschus esculentus粘液（AEM）的ph敏感丙烯酸移植水凝胶（移植物复合材料），以改善克罗恩病和溃疡性结肠炎的治疗效果。红外光谱（FT-IR）、扫描电镜（SEM）和x射线衍射（XRD）证实了成功接枝的多孔结构有利于药物负载。药物释放研究表明，PAS在酸性条件下释放较慢，在碱性条件下释放较快，模拟了胃肠道的pH变化。释放动力学证实了korsmemeyer - peppas模型，表现出非菲克式扩散行为，特别是在碱性介质中，R2值在0.9874 ~ 0.9989之间。生物相容性评估，包括细胞毒性、血液相容性和急性口服毒性试验，表明移植物复合材料可以安全使用。体内研究证实，PAS的半衰期从1.119小时增加到4.395小时。这种ph敏感的给药系统为PAS在结肠中的受控、靶向释放提供了一种有希望的方法，提高了炎症性肠病患者的治疗效果。这种移植复合材料的成功开发代表了胃肠道疾病生物相容性和控制药物递送的重大进步。

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来源期刊

European Journal of Pharmaceutics and Biopharmaceutics 医学-药学

CiteScore

8.80

自引率

4.10%

发文量

211

审稿时长

36 days

期刊介绍： The European Journal of Pharmaceutics and Biopharmaceutics provides a medium for the publication of novel, innovative and hypothesis-driven research from the areas of Pharmaceutics and Biopharmaceutics. Topics covered include for example: Design and development of drug delivery systems for pharmaceuticals and biopharmaceuticals (small molecules, proteins, nucleic acids) Aspects of manufacturing process design Biomedical aspects of drug product design Strategies and formulations for controlled drug transport across biological barriers Physicochemical aspects of drug product development Novel excipients for drug product design Drug delivery and controlled release systems for systemic and local applications Nanomaterials for therapeutic and diagnostic purposes Advanced therapy medicinal products Medical devices supporting a distinct pharmacological effect.