Targeting ferroptosis in cervical cancer: Mechanistic insights and therapeutic opportunities

IF 3.7 2区生物学 Q2 CELL BIOLOGY

Cellular signalling Pub Date : 2025-09-10 DOI:10.1016/j.cellsig.2025.112122

Shunji An , Anna Han , Zhenhua Lin , Haiyan Quan

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引用次数: 0

Abstract

Cervical cancer is the fourth most common malignancy among women worldwide. Despite standard chemoradiotherapy, a significant number of patients experience recurrence or distant metastasis. Accumulating evidence highlights ferroptosis—an iron-dependent form of regulated cell death driven by lipid peroxidation (LPO)—as a key mechanism influencing cervical carcinogenesis and treatment outcomes. Ferroptosis is marked by intracellular iron overload, excessive reactive oxygen species (ROS) production, and loss of redox balance. This review provides a comprehensive overview of the emerging roles of ferroptosis in the initiation, progression, and therapeutic resistance of cervical cancer. We outline the regulatory networks and signaling pathways that control ferroptosis in cervical cancer cells and assess the therapeutic potential of inducing ferroptosis using small-molecule compounds and nanomedicine approaches. Additionally, we discuss the prognostic value of ferroptosis-related genes (FRGs), their association with immune infiltration, and their implications for personalized immunotherapy. Collectively, these insights emphasize the translational promise of targeting ferroptosis as a novel strategy for precision oncology and targeted therapy in cervical cancer.

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靶向子宫颈癌铁下垂：机制见解和治疗机会

子宫颈癌是全世界妇女中第四大最常见的恶性肿瘤。尽管标准的放化疗，相当多的患者经历复发或远处转移。越来越多的证据表明，铁中毒是一种由脂质过氧化（LPO）驱动的铁依赖性细胞死亡形式，是影响宫颈癌发生和治疗结果的关键机制。铁下垂的特征是细胞内铁超载，活性氧（ROS）产生过多，以及氧化还原平衡的丧失。本文综述了铁下垂在宫颈癌的发生、发展和治疗抵抗中的作用。我们概述了宫颈癌细胞中控制铁下垂的调控网络和信号通路，并评估了使用小分子化合物和纳米药物方法诱导铁下垂的治疗潜力。此外，我们还讨论了嗜铁相关基因（FRGs）的预后价值，它们与免疫浸润的关系，以及它们对个性化免疫治疗的影响。总的来说，这些见解强调了靶向铁下垂作为宫颈癌精确肿瘤学和靶向治疗的新策略的转化前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cellular signalling 生物-细胞生物学

CiteScore

8.40

自引率

0.00%

发文量

250

审稿时长

27 days

期刊介绍： Cellular Signalling publishes original research describing fundamental and clinical findings on the mechanisms, actions and structural components of cellular signalling systems in vitro and in vivo. Cellular Signalling aims at full length research papers defining signalling systems ranging from microorganisms to cells, tissues and higher organisms.