Is the CncC/Keap1 complex a major factor in conferring pesticide resistance in arthropods? - A critical review

IF 3.7 2区农林科学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Insect Biochemistry and Molecular Biology Pub Date : 2025-09-10 DOI:10.1016/j.ibmb.2025.104400

Dries Amezian, Thomas Van Leeuwen

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Abstract

The CncC/Keap1 signalling pathway regulates antioxidant and detoxification gene expression in arthropods and is frequently associated with metabolic insecticide resistance. This review critically assesses evidence for its role in resistance phenotypes across key pest species. Although overactivation of CncC/Keap1 correlates with increased detoxification enzyme expression and pesticide tolerance, causal mutations in the coding or regulatory regions of CncC, Keap1, or Maf remain unidentified. We evaluate the evidence supporting the role of CncC/Keap1 in pesticide resistance in insects and mites and report the latest advancements in our understanding of this system in arthropods. We further highlight the need for unbiased genetic mapping and reverse genetic approaches to resolve the mechanisms of constitutive CncC activation in resistant populations. Understanding these mechanisms is crucial for elucidating the origins of metabolic resistance and developing sustainable pest management strategies.

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CncC/Keap1复合体是节肢动物产生农药抗性的主要因素吗？-批评性评论

CncC/Keap1信号通路调节节肢动物抗氧化和解毒基因的表达，并经常与代谢性杀虫剂抗性相关。本综述批判性地评估了其在主要害虫物种抗性表型中的作用的证据。尽管CncC/Keap1的过度激活与解毒酶表达增加和农药耐受性相关，但CncC、Keap1或Maf编码或调控区域的因果突变仍未确定。我们评估了支持CncC/Keap1在昆虫和螨的农药抗性中的作用的证据，并报告了我们在节肢动物中对该系统的最新理解进展。我们进一步强调需要无偏遗传作图和反向遗传方法来解决耐药群体中组成型CncC激活的机制。了解这些机制对于阐明代谢抗性的起源和制定可持续的害虫管理策略至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Insect Biochemistry and Molecular Biology 生物-昆虫学

CiteScore

7.40

自引率

5.30%

发文量

105

审稿时长

40 days

期刊介绍： This international journal publishes original contributions and mini-reviews in the fields of insect biochemistry and insect molecular biology. Main areas of interest are neurochemistry, hormone and pheromone biochemistry, enzymes and metabolism, hormone action and gene regulation, gene characterization and structure, pharmacology, immunology and cell and tissue culture. Papers on the biochemistry and molecular biology of other groups of arthropods are published if of general interest to the readership. Technique papers will be considered for publication if they significantly advance the field of insect biochemistry and molecular biology in the opinion of the Editors and Editorial Board.