Assessment of scintigraphic imaging with Terbium-161: A visual and quantitative analysis

IF 1.8 3区工程技术 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Applied Radiation and Isotopes Pub Date : 2025-09-09 DOI:10.1016/j.apradiso.2025.112171

Florian Rosar , Sven Petto , Sebastian Ganz , Caroline Burgard , Stephan Maus , Mark Bartholomä , Isabelle Miederer , Mathias Schreckenberger , Samer Ezziddin , Andrea Schaefer-Schuler

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引用次数: 0

Abstract

The Auger emitter ¹⁶¹Tb is an increasingly discussed radionuclide for targeted radionuclide therapy. The aim of this study was to assess the feasibility of scintigraphic imaging with ¹⁶¹Tb in terms of image quality and quantitative capabilities by phantom measurements and to evaluate the suitability of this radionuclide for clinical use. Phantom measurements were conducted using a standardized NEMA IEC body phantom filled with activity concentrations ranging from 2.5 GBq to 100 MBq. Both visual and quantitative analyses were performed, including assessment of the image calibration factor (CF), as well as the recovery coefficient (RC) and the contrast-to-noise ratio (CNR) of the individual spheres. The results observed in this study demonstrate that quantitative SPECT/CT imaging with ¹⁶¹Tb is feasible over a wide range of activity making this radionuclide suitable for clinical applications. Acquiring a total of at least 5 million photopeak counts enables visual detectability of lesions of diameter lower than 20 mm and quantitative calibration for dosimetry purposes.

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Terbium-161的闪烁成像评估：视觉和定量分析

俄歇发射体161Tb是一种越来越多地被讨论用于靶向放射性核素治疗的放射性核素。本研究的目的是评估161Tb放射成像在图像质量和通过幻影测量的定量能力方面的可行性，并评估该放射性核素在临床应用的适用性。幻影测量使用标准的NEMA IEC体幻影进行，体幻影充满活性浓度范围从2.5 GBq到100 MBq。进行了视觉和定量分析，包括评估图像校准因子（CF）、恢复系数（RC）和单个球体的噪比（CNR）。本研究中观察到的结果表明，161Tb的定量SPECT/CT成像在广泛的活性范围内是可行的，使该放射性核素适合临床应用。获得至少500万个光峰计数，可以对直径小于20mm的病变进行视觉检测，并可用于剂量学目的的定量校准。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Applied Radiation and Isotopes 工程技术-核科学技术

CiteScore

3.00

自引率

12.50%

发文量

406

审稿时长

13.5 months

期刊介绍： Applied Radiation and Isotopes provides a high quality medium for the publication of substantial, original and scientific and technological papers on the development and peaceful application of nuclear, radiation and radionuclide techniques in chemistry, physics, biochemistry, biology, medicine, security, engineering and in the earth, planetary and environmental sciences, all including dosimetry. Nuclear techniques are defined in the broadest sense and both experimental and theoretical papers are welcome. They include the development and use of α- and β-particles, X-rays and γ-rays, neutrons and other nuclear particles and radiations from all sources, including radionuclides, synchrotron sources, cyclotrons and reactors and from the natural environment. The journal aims to publish papers with significance to an international audience, containing substantial novelty and scientific impact. The Editors reserve the rights to reject, with or without external review, papers that do not meet these criteria. Papers dealing with radiation processing, i.e., where radiation is used to bring about a biological, chemical or physical change in a material, should be directed to our sister journal Radiation Physics and Chemistry.