Ziying Pan , Zhengzheng Wang , Mengxia Zou , Huichan Zhai , Congyu Zhou , Qingping Wu , Jiahui Zeng , Xiuhua Lin , Tingting Liu , Yu Ding , Juan Wang
{"title":"Harness of multifunctional nanozymes: Focusing on material construction to food safety detection and monitoring","authors":"Ziying Pan , Zhengzheng Wang , Mengxia Zou , Huichan Zhai , Congyu Zhou , Qingping Wu , Jiahui Zeng , Xiuhua Lin , Tingting Liu , Yu Ding , Juan Wang","doi":"10.1016/j.ccr.2025.217153","DOIUrl":null,"url":null,"abstract":"<div><div>Abstract</div><div>As people pay more and more attention to food safety, the demand for fast, sensitive and reliable detection technologies is also growing. However, traditional detection technologies usually have the disadvantages of low sensitivity, complicated procedures and poor adaptability to various food matrices. Natural enzymes, due to their rapid reaction rates, are widely used in various rapid detection platforms, driving the development of traditional detection methods. However, the complexity of their extraction and relatively high cost limit their application. Nanozymes, which mimic the catalytic activity of natural enzymes, offer advantages, including lower costs, ease of preparation, and excellent stability, making them a promising alternative to natural enzymes. However, most nanozymes are monofunctional, and such single-function systems often exhibit limited substrate scope, poor adaptability, and weak signal amplification, restricting their broader application. In contrast, multifunctional nanozymes (MFNZs) can combine enzyme-mimicking catalysis (e.g., peroxidase) with the intrinsic physical properties (optical, magnetic, photothermal) endowed by nanoscale coordination structures, providing a revolutionary solution for food safety by enabling synergistic cascade reactions, signal amplification, and simplified sample processing. However, how to accurately combine multiple functions based on the different mechanisms of action of MFNZs has not yet been clearly explained. Therefore, it is necessary to conduct a systematic review of the design principles, classification and functional combination of MFNZs. This review systematically explores the rational design strategies, catalytic mechanisms, and functional classification of MFNZs, emphasizing how engineered coordination environments at the nanoscale underpin their multifunctionality. We assess the application of MFNZ-based multi-mode biosensors for detecting diverse food contaminants. This review aims to provide foundational insights for advancing MFNZs as powerful, coordination chemistry-driven tools in next-generation food safety monitoring and biosensing.</div></div>","PeriodicalId":289,"journal":{"name":"Coordination Chemistry Reviews","volume":"548 ","pages":"Article 217153"},"PeriodicalIF":23.5000,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Coordination Chemistry Reviews","FirstCategoryId":"92","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0010854525007234","RegionNum":1,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, INORGANIC & NUCLEAR","Score":null,"Total":0}
引用次数: 0
Abstract
As people pay more and more attention to food safety, the demand for fast, sensitive and reliable detection technologies is also growing. However, traditional detection technologies usually have the disadvantages of low sensitivity, complicated procedures and poor adaptability to various food matrices. Natural enzymes, due to their rapid reaction rates, are widely used in various rapid detection platforms, driving the development of traditional detection methods. However, the complexity of their extraction and relatively high cost limit their application. Nanozymes, which mimic the catalytic activity of natural enzymes, offer advantages, including lower costs, ease of preparation, and excellent stability, making them a promising alternative to natural enzymes. However, most nanozymes are monofunctional, and such single-function systems often exhibit limited substrate scope, poor adaptability, and weak signal amplification, restricting their broader application. In contrast, multifunctional nanozymes (MFNZs) can combine enzyme-mimicking catalysis (e.g., peroxidase) with the intrinsic physical properties (optical, magnetic, photothermal) endowed by nanoscale coordination structures, providing a revolutionary solution for food safety by enabling synergistic cascade reactions, signal amplification, and simplified sample processing. However, how to accurately combine multiple functions based on the different mechanisms of action of MFNZs has not yet been clearly explained. Therefore, it is necessary to conduct a systematic review of the design principles, classification and functional combination of MFNZs. This review systematically explores the rational design strategies, catalytic mechanisms, and functional classification of MFNZs, emphasizing how engineered coordination environments at the nanoscale underpin their multifunctionality. We assess the application of MFNZ-based multi-mode biosensors for detecting diverse food contaminants. This review aims to provide foundational insights for advancing MFNZs as powerful, coordination chemistry-driven tools in next-generation food safety monitoring and biosensing.
期刊介绍:
Coordination Chemistry Reviews offers rapid publication of review articles on current and significant topics in coordination chemistry, encompassing organometallic, supramolecular, theoretical, and bioinorganic chemistry. It also covers catalysis, materials chemistry, and metal-organic frameworks from a coordination chemistry perspective. Reviews summarize recent developments or discuss specific techniques, welcoming contributions from both established and emerging researchers.
The journal releases special issues on timely subjects, including those featuring contributions from specific regions or conferences. Occasional full-length book articles are also featured. Additionally, special volumes cover annual reviews of main group chemistry, transition metal group chemistry, and organometallic chemistry. These comprehensive reviews are vital resources for those engaged in coordination chemistry, further establishing Coordination Chemistry Reviews as a hub for insightful surveys in inorganic and physical inorganic chemistry.