Predictive Nomogram for Risk Stratification After Transoral Surgery in HPV-Related Oropharyngeal Cancer.

IF 2.2 3区医学 Q1 OTORHINOLARYNGOLOGY

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck Pub Date : 2025-09-12 DOI:10.1002/hed.70038

Andrea Costantino, Vinidh Paleri, F Christopher Holsinger, Uthman Alamoudi, Bruce H Haughey, J Scott Magnuson

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引用次数: 0

Abstract

Background: This study develops a predictive model that stratifies patients with HPV-related oropharyngeal squamous cell carcinoma (OPSCC) by survival outcomes based on adjuvant treatment received following transoral surgery (TOS).

Methods: Patients receiving primary TOS with or without adjuvant were included from the National Cancer Database. A predictive nomogram was constructed using a multivariable Cox regression model.

Results: A total of 5569 patients were included. The model based on 11 demographic, socioeconomic, and clinical variables stratified patients into low-risk (57%), intermediate-risk (35.5%), and high-risk (7.5%) cohorts, with significant differences in survival between the risk groups. No association with better survival was found for adjuvant treatment in the low-risk group. A significant association between adjuvant treatment and improved survival was measured in the intermediate-risk and high-risk cohorts.

Conclusions: This predictive model effectively stratified OPSCC patients by risk, revealing outcome differences based on adjuvant treatment. Further studies are required to validate these findings.

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hpv相关口咽癌经口手术后风险分层的预测Nomogram。

背景：本研究建立了一个预测模型，根据经口手术（TOS）后接受辅助治疗的生存结果对hpv相关口咽鳞状细胞癌（OPSCC）患者进行分层。方法：从国家癌症数据库中纳入接受有或无辅助治疗的原发性TOS患者。采用多变量Cox回归模型构建预测模态图。结果：共纳入5569例患者。该模型基于11个人口统计学、社会经济和临床变量，将患者分为低危（57%）、中危（35.5%）和高危（7.5%）队列，风险组之间的生存率存在显著差异。在低危组中，辅助治疗与更好的生存率没有关联。在中危和高危队列中，辅助治疗与改善生存率之间存在显著关联。结论：该预测模型根据风险对OPSCC患者进行了有效的分层，揭示了基于辅助治疗的结果差异。需要进一步的研究来验证这些发现。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Head and Neck-Journal for the Sciences and Specialties of the Head and Neck 医学-耳鼻喉科学

CiteScore

7.00

自引率

6.90%

发文量

278

审稿时长

1.6 months

期刊介绍： Head & Neck is an international multidisciplinary publication of original contributions concerning the diagnosis and management of diseases of the head and neck. This area involves the overlapping interests and expertise of several surgical and medical specialties, including general surgery, neurosurgery, otolaryngology, plastic surgery, oral surgery, dermatology, ophthalmology, pathology, radiotherapy, medical oncology, and the corresponding basic sciences.