Clinical Efficacy of Different Epidermal Dressings in Patients with Second Degree Burns: A Systematic Review and Bayesian Network Meta-Analysis.

Abstract

BackgroundA variety of dressings are used for burn patients in the clinic, and the difference in efficacy between different dressings is controversial Therefore, we used Bayesian net meta-analysis to evaluate the clinical efficacy of 14 dressings in patients with second-degree burns.MethodsPubMed, Cochrane Library, Web of Science, Embase, and China Knowledge Network databases were searched to collect randomised controlled trials on different dressings used in the treatment of second-degree burns that met the inclusion criteria from 2010-01 to 2024-12 in each database. Literature was screened by 2 investigators, who independently collected and organised the data for extraction, assessed the quality of the included studies using the Cochrane Risk of Bias tool and Review Manager 5.4, and scored the evidence using GRADEPro. Network meta-analysis (NMA) was performed using R Studio, and SUCRA was used to rank the included dressings for each outcome indicator.ResultsA total of 28 studies containing 2072 patients with second-degree burns and 14 different interventions were included, and the results of the network meta-analysis showed that:1) the top 3 results of the ranked probability of wound healing rate within 2 weeks were: human amniotic membrane (85.3%)>Recombinant human granulocyte macrophage colony stimulating factor(81.7%)>Recombinant Human Erythropoietin(78.1%); ②The top three results in terms of wound healing time were: Recombinant Human Erythropoietin(1.6%)ConclusionBased on the SUCRA values and NMA results, we found that Human amniotic membrane can significantly increase the wound healing rate of patients with second-degree burns, Recombinant Human Erythropoietin can significantly shorten the wound healing time, and Heparin has a better effect on reducing the pain of burn patients.However, limited by the quality of the included literature, further high-quality clinical studies are needed to confirm this.