Unmasked: transposable elements as drivers and targets in cancer.

IF 16.3 2区 生物学 Q1 GENETICS & HEREDITY
Mitchell F Grinwald, Wesley N Saintilnord, Ting Wang
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引用次数: 0

Abstract

Transposable elements (TEs) - long considered 'junk DNA' - challenge the binary of threat and therapeutic opportunity in cancer. Their reactivation is not a singular event but a convergence of evolutionary legacy, regulatory disruption, and technological insight. This review synthesizes a growing body of work that positions TEs as both catalysts and antagonists of the tumor state. Across regulatory control, viral mimicry, protein-coding potential, and antigen presentation, TEs blur the line between harm and utility. Each example reflects a broader theme: context defines consequence. By tracing historical shifts and technological advances, we argue for an integrated view: one where TEs are not just anomalies, but dynamic agents in the complexity of cancer.

揭示:转座因子在癌症中的驱动和靶标。
转座因子(te)——长期以来被认为是“垃圾DNA”——挑战了癌症的威胁和治疗机会。它们的重新激活不是一个单一的事件,而是进化遗产、监管破坏和技术洞察力的融合。这篇综述综合了越来越多的工作,将TEs定位为肿瘤状态的催化剂和拮抗剂。通过调控控制、病毒模仿、蛋白质编码潜能和抗原呈递,TEs模糊了危害和效用之间的界限。每个例子都反映了一个更广泛的主题:上下文定义结果。通过追溯历史变迁和技术进步,我们提出了一种综合观点:te不仅是异常现象,而且是癌症复杂性中的动态动因。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Trends in Genetics
Trends in Genetics 生物-遗传学
CiteScore
20.90
自引率
0.90%
发文量
160
审稿时长
6-12 weeks
期刊介绍: Launched in 1985, Trends in Genetics swiftly established itself as a "must-read" for geneticists, offering concise, accessible articles covering a spectrum of topics from developmental biology to evolution. This reputation endures, making TiG a cherished resource in the genetic research community. While evolving with the field, the journal now embraces new areas like genomics, epigenetics, and computational genetics, alongside its continued coverage of traditional subjects such as transcriptional regulation, population genetics, and chromosome biology. Despite expanding its scope, the core objective of TiG remains steadfast: to furnish researchers and students with high-quality, innovative reviews, commentaries, and discussions, fostering an appreciation for advances in genetic research. Each issue of TiG presents lively and up-to-date Reviews and Opinions, alongside shorter articles like Science & Society and Spotlight pieces. Invited from leading researchers, Reviews objectively chronicle recent developments, Opinions provide a forum for debate and hypothesis, and shorter articles explore the intersection of genetics with science and policy, as well as emerging ideas in the field. All articles undergo rigorous peer-review.
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