Neurodevelopmental Outcomes of Very Low Birth Weight Infants With Transient Hypothyroxinaemia of Prematurity.

IF 2.1 4区 医学 Q1 PEDIATRICS
Acta Paediatrica Pub Date : 2025-09-12 DOI:10.1111/apa.70302
Sophie S L Yeow, Charis H Y Chung, Wilfred H S Wong, Khair Jalal, Mabel S C Wong, Wing-Shan Queenie See
{"title":"Neurodevelopmental Outcomes of Very Low Birth Weight Infants With Transient Hypothyroxinaemia of Prematurity.","authors":"Sophie S L Yeow, Charis H Y Chung, Wilfred H S Wong, Khair Jalal, Mabel S C Wong, Wing-Shan Queenie See","doi":"10.1111/apa.70302","DOIUrl":null,"url":null,"abstract":"<p><strong>Aim: </strong>Transient hypothyroxinaemia of prematurity affects very low birth weight (VLBW) infants born prematurely. The relationship between transient hypothyroxinaemia of prematurity (THOP) and adverse neurodevelopmental outcomes is still controversial. The present study aimed to compare the neurodevelopmental outcomes between those with VLBW infants with THOP and those without.</p><p><strong>Methods: </strong>This was a single tertiary neonatal centre retrospective study comparing the neurodevelopmental outcome using Griffiths Mental Development Scales-Extended Revised between VLBW infants (birth weight less than or equal to 1500 g) with THOP to those without based on one-to-one age and gender matching from 2011 to 2021.</p><p><strong>Result: </strong>Forty-two VLBW infants with THOP and 42 VLBW infants without THOP were matched by age and gender. None of the infants with THOP received thyroxine supplementation. The prevalence of THOP is 6.86%. The mortality rate for infants with THOP was 14.3%. There was no significant difference in neonatal complications and neurodevelopmental outcomes between infants with THOP (70%) and infants without THOP (70.7%).</p><p><strong>Conclusion: </strong>We showed that there was no difference in neurodevelopmental outcomes between those with THOP without thyroxine supplementation and those without THOP.</p>","PeriodicalId":55562,"journal":{"name":"Acta Paediatrica","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Paediatrica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1111/apa.70302","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"PEDIATRICS","Score":null,"Total":0}
引用次数: 0

Abstract

Aim: Transient hypothyroxinaemia of prematurity affects very low birth weight (VLBW) infants born prematurely. The relationship between transient hypothyroxinaemia of prematurity (THOP) and adverse neurodevelopmental outcomes is still controversial. The present study aimed to compare the neurodevelopmental outcomes between those with VLBW infants with THOP and those without.

Methods: This was a single tertiary neonatal centre retrospective study comparing the neurodevelopmental outcome using Griffiths Mental Development Scales-Extended Revised between VLBW infants (birth weight less than or equal to 1500 g) with THOP to those without based on one-to-one age and gender matching from 2011 to 2021.

Result: Forty-two VLBW infants with THOP and 42 VLBW infants without THOP were matched by age and gender. None of the infants with THOP received thyroxine supplementation. The prevalence of THOP is 6.86%. The mortality rate for infants with THOP was 14.3%. There was no significant difference in neonatal complications and neurodevelopmental outcomes between infants with THOP (70%) and infants without THOP (70.7%).

Conclusion: We showed that there was no difference in neurodevelopmental outcomes between those with THOP without thyroxine supplementation and those without THOP.

极低出生体重儿伴短暂性早产儿甲状腺功能低下的神经发育结局。
目的:一过性甲减血症对极低出生体重儿的影响。短暂性早产儿甲状腺功能减退症(THOP)与不良神经发育结局之间的关系仍存在争议。本研究旨在比较有THOP和无THOP的VLBW婴儿的神经发育结果。方法:这是一项单一的第三新生儿中心回顾性研究,比较2011年至2021年期间患有THOP的VLBW婴儿(出生体重小于或等于1500 g)与未患有THOP的婴儿(基于一对一年龄和性别匹配)的神经发育结果。结果:42例VLBW患儿有THOP, 42例VLBW患儿无THOP,年龄、性别匹配。THOP患儿均未接受甲状腺素补充治疗。THOP患病率为6.86%。THOP婴儿死亡率为14.3%。新生儿并发症和神经发育结局在有THOP的婴儿(70%)和没有THOP的婴儿(70.7%)之间没有显著差异。结论:我们发现在不补充甲状腺素的THOP组和不补充THOP组的神经发育结局没有差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
Acta Paediatrica
Acta Paediatrica 医学-小儿科
CiteScore
6.50
自引率
5.30%
发文量
384
审稿时长
2-4 weeks
期刊介绍: Acta Paediatrica is a peer-reviewed monthly journal at the forefront of international pediatric research. It covers both clinical and experimental research in all areas of pediatrics including: neonatal medicine developmental medicine adolescent medicine child health and environment psychosomatic pediatrics child health in developing countries
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:604180095
Book学术官方微信