Sleep and circadian effects on the incretin system.

IF 2 Q4 CLINICAL NEUROLOGY

Current Sleep Medicine Reports Pub Date : 2025-12-01 Epub Date: 2025-05-28 DOI:10.1007/s40675-025-00337-9

Robin K Yuan, Kirsi-Marja Zitting

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引用次数: 0

Abstract

Purpose of review: Little is known about how incretins interact with sleep and circadian factors, both of which influence metabolic outcomes. We review evidence that sleep, circadian rhythms, and their disturbances impact incretin secretion and discuss clinical applications for GLP-1/GIP-RA drugs in sleep medicine and areas for future research.

Recent findings: GLP-1 secretion exhibits a circadian rhythm which may be disrupted by high-fat diet, meal timing, and gut dysbiosis. Insufficient sleep may alter the timing of postprandial GLP-1 release, and the circadian rhythm of GLP-1 secretion is blunted in patients with metabolic conditions such as obesity or diabetes. Lastly, the FDA has approved the use of tirzepatide (a GLP-1/GIP-RA drug) for treating obstructive sleep apnea.

Summary: Evidence suggests that sleep and circadian rhythms impact the incretin system, although findings are somewhat mixed due to the variety of methods employed. In light of the growing interest in new clinical applications for incretin therapies, more research is needed to fully understand the relationship between sleep, circadian rhythms, and incretin secretion.

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睡眠和昼夜节律对肠促胰岛素系统的影响。

综述目的：关于肠促胰岛素如何与睡眠和昼夜节律因素相互作用知之甚少，这两者都影响代谢结果。我们回顾了睡眠、昼夜节律及其干扰影响肠促胰岛素分泌的证据，并讨论了GLP-1/GIP-RA药物在睡眠医学和未来研究领域的临床应用。最近的研究发现：GLP-1分泌具有昼夜节律，可被高脂肪饮食、进餐时间和肠道生态失调打乱。睡眠不足可能会改变餐后GLP-1释放的时间，在肥胖或糖尿病等代谢疾病患者中，GLP-1分泌的昼夜节律变迟钝。最后，FDA批准使用tizepatide（一种GLP-1/GIP-RA药物）治疗阻塞性睡眠呼吸暂停。总结：有证据表明，睡眠和昼夜节律影响肠促胰岛素系统，尽管由于采用的方法不同，研究结果有些混杂。鉴于人们对肠促胰岛素治疗的新临床应用越来越感兴趣，需要更多的研究来充分了解睡眠、昼夜节律和肠促胰岛素分泌之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Sleep Medicine Reports Medicine-Pulmonary and Respiratory Medicine

CiteScore

2.50

自引率

5.60%

发文量

期刊介绍： Current Sleep Medicine Reports aims to review the most important, recently published articles in the field of sleep medicine. By providing clear, insightful, balanced contributions by international experts, the journal intends to serve all those involved in the care and prevention of sleep conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas such as insomnia, narcolepsy, sleep apnea, circadian rhythm disorders, and parasomnias. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also occasionally provided.