[A Case of Endometrial Metastasis in Lung Adenocarcinoma 
after EGFR-TKIs Treatment Failure and Literature Review].

Q4 Medicine
Fangqian Shen, Zuling Hu, Hua Yang, Puyu Liu, Yuju Bai, Jianguo Zhou, Hu Ma
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引用次数: 0

Abstract

The incidence and mortality rates of lung cancer remain high, making it the leading cause of cancer-related deaths. In women, the predominant histological subtype is lung adenocarcinoma, commonly associated with epidermal growth factor receptor (EGFR) mutations, and EGFR-tyrosine kinase inhibitors (EGFR-TKIs) can significantly improve patient prognosis. Metastasis of primary lung cancer to the endometrium is extremely rare and is often misdiagnosed as a primary reproductive system tumor, and its occurrence indicates poor prognosis. This article reports a case of an advanced lung adenocarcinoma patient with EGFR mutation, who developed abnormal vaginal bleeding after EGFR-TKIs treatment failure, and biopsy confirmed endometrial metastasis. A review of similar cases is also presented.
.

[1例EGFR-TKIs治疗失败后肺腺癌子宫内膜转移
及文献复习]。
肺癌的发病率和死亡率仍然很高,使其成为癌症相关死亡的主要原因。在女性中,主要的组织学亚型是肺腺癌,通常与表皮生长因子受体(EGFR)突变相关,EGFR-酪氨酸激酶抑制剂(EGFR- tkis)可以显著改善患者预后。原发性肺癌向子宫内膜转移极为罕见,常被误诊为原发性生殖系统肿瘤,其发生预示预后不良。本文报道一例晚期EGFR突变肺腺癌患者,EGFR- tkis治疗失败后出现阴道异常出血,活检证实子宫内膜转移。对类似的案例也进行了回顾。
。
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来源期刊
中国肺癌杂志
中国肺癌杂志 Medicine-Pulmonary and Respiratory Medicine
CiteScore
1.40
自引率
0.00%
发文量
5131
审稿时长
14 weeks
期刊介绍: Chinese Journal of Lung Cancer(CJLC, pISSN 1009-3419, eISSN 1999-6187), a monthly Open Access journal, is hosted by Chinese Anti-Cancer Association, Chinese Antituberculosis Association, Tianjin Medical University General Hospital. CJLC was indexed in DOAJ, EMBASE/SCOPUS, Chemical Abstract(CA), CSA-Biological Science, HINARI, EBSCO-CINAHL,CABI Abstract, Global Health, CNKI, etc. Editor-in-Chief: Professor Qinghua ZHOU.
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