Relationship between Helicobacter pylori infection and the development of metabolic dysfunction and associated steatotic liver disease.

Abstract

This research is to explore the relationship between Helicobacter pylori (H. pylori) infection and the development of metabolic dysfunction and metabolic dysfunction-associated steatotic liver disease (MASLD), based on research by Ye et al. Their investigation analyzed the association of H. pylori infection with obesity, glucose, lipids, blood pressure, and MASLD in Chinese adults, through a cross-sectional study of 28624 participants. Clinical data analysis demonstrated that H. pylori-positive participants exhibited significantly higher ages, blood glucose, total cholesterol, low-density lipoprotein, body mass index, systolic and diastolic blood pressure levels, and greater MASLD detection rates compare to the H. pylo ri-negative participants. These differences achieved statistical significance (P < 0.05). Multivariate analysis identified, elevated glucose, body mass index, and diastolic pressure as independent risk factors for H. pylori infection, while high-density lipoprotein demonstrated protective effects. These findings suggest that H. pylori infection may contribute to metabolic disturbances and MASLD.