Heterogeneity and characteristic changes in cardiomyocytes and non‑cardiomyocytes following myocardial infarction: Insights from single‑cell sequencing analysis (Review).

Abstract

Myocardial infarction (MI) is an important pathological event in cardiovascular disease and the heterogeneous changes in cardiomyocytes and non‑cardiomyocytes that occur following its occurrence have a profound effect on cardiac repair and functional recovery. Single‑cell sequencing, a novel technology for the analysis of tissues at the single‑cell level, permits a comprehensive insight into the heterogeneity of different cell populations. The current review presented a summary of the application of single‑cell sequencing to detect the heterogeneity of cardiomyocytes and non‑cardiomyocytes following MI. It focused on the classification and changes of cell clusters and explored the mechanisms of post‑infarction cardiac regeneration and remodeling with the aim of providing a theoretical foundation for identifying potential targets to enhance the diagnosis and treatment of post‑infarction cardiac remodeling.