Cortical visual field representation and data integration following optic neuritis

IF 4.5 2区医学 Q1 NEUROIMAGING

NeuroImage Pub Date : 2025-09-09 DOI:10.1016/j.neuroimage.2025.121449

Ruth Abulafia , Pieter B. de Best , Ayelet McKyton , Adi Vaknin-Dembinsky , Panayiota Petrou , Atira S. Bick , Netta Levin

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引用次数: 0

Abstract

Optic neuritis (ON) is an inflammatory, demyelinating optic neuropathy commonly associated with multiple sclerosis. Its clinical presentation typically includes monocular vision loss, with most visual functions recovering within several weeks. In addition to spontaneous remyelination, brain adaptation has been suggested to play a role in the recovery process.

To further investigate this hypothesis, we examined cortical visual field representation and data integration during the first year following a first-ever ON episode. Eight ON participants and ten controls underwent fMRI scans under three viewing conditions: two monocular conditions (affected/fellow eye for ON; dominant/non-dominant eye for controls) and one binocular condition (both eyes open). For each condition, population receptive field (pRF) and connective field (CF) modeling were applied to assess spatial properties and sampling extent across the early visual cortical hierarchy (V1–V3).

Consistent with previous studies, controls demonstrated an increase in average pRF and CF sizes along the visual hierarchy, with no significant differences between viewing conditions. In contrast, the ON group exhibited unique patterns. In the fellow eye condition, the typical pRF size increase along the visual hierarchy was absent, primarily due to reduced pRF sizes in V3. Additionally, in the affected eye, CF sizes were significantly larger than in the fellow eye.

These modulations may reflect enhanced resolution for the unaffected eye and an increased extent of data processing when visual input is impaired (originating from the affected nerve). Therefore, we suggest that these cortical changes may be part of a spatial adaptation mechanism.

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视神经炎后皮层视野表现与资料整合。

视神经炎（ON）是一种炎性、脱髓鞘性视神经病变，通常与多发性硬化症相关。其临床表现通常包括单眼视力丧失，多数视觉功能在数周内恢复。除了自发性髓鞘再生外，脑适应也被认为在恢复过程中发挥作用。为了进一步研究这一假设，我们在首次ON发作后的第一年检查了皮质视野表征和数据整合。8名ON参与者和10名对照者在三种观看条件下进行了功能磁共振成像扫描：两种单眼条件（ON的受影响/同伴眼；对照组的优势/非优势眼）和一种双眼条件（双眼睁开）。在每种情况下，应用群体接受野（pRF）和连接野（CF）模型来评估早期视觉皮层层次（V1-V3）的空间特性和采样范围。与先前的研究一致，对照组显示沿视觉层次的平均pRF和CF大小增加，在观看条件之间没有显着差异。相比之下，ON组表现出独特的模式。在其他眼睛状况下，典型的pRF大小沿视觉层次增加不存在，主要是由于V3的pRF大小减少。此外，在受影响的眼睛中，CF的大小明显大于正常眼睛。这些调节可能反映了未受影响的眼睛的分辨率增强，以及当视觉输入受损（源自受影响的神经）时数据处理程度的增加。因此，我们认为这些皮质变化可能是空间适应机制的一部分。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NeuroImage 医学-核医学

CiteScore

11.30

自引率

10.50%

发文量

809

审稿时长

63 days

期刊介绍： NeuroImage, a Journal of Brain Function provides a vehicle for communicating important advances in acquiring, analyzing, and modelling neuroimaging data and in applying these techniques to the study of structure-function and brain-behavior relationships. Though the emphasis is on the macroscopic level of human brain organization, meso-and microscopic neuroimaging across all species will be considered if informative for understanding the aforementioned relationships.