Effects of Age and BMI on Histamine H3 Receptor Availability in Healthy Humans.

IF 2.5 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Molecular Imaging and Biology Pub Date : 2025-09-12 DOI:10.1007/s11307-025-02047-8

Yanghong Yang, Waleed Ibrahim, Paul Gravel, Brian Pittman, Jocelyn Hoye, Ryan Cool, Faranak Ebrahimian Sadabad, Ming-Qiang Zheng, Christopher Pittenger, Jean-Dominique Gallezot, Richard E Carson, Henry Huang, Rajiv Radhakrishnan, David Matuskey

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引用次数: 0

Abstract

Purpose: To assess alterations in H3R availability with age and body mass index (BMI) in healthy humans using in vivo [¹¹C]GSK189254 positron emission tomography (PET) imaging.

Procedure: Twenty-four healthy individuals (2 females, 22 males; age range 20-47 years) were scanned with [¹¹C]GSK189254 with High-Resolution Research Tomograph (HRRT) or HR plus scanner. Regional V_T (volume of distribution) values were computed using the two-tissue compartment model. The correlation between V_T and age, BMI were examined, adjusting for relevant potential confounding effects of age or gender and injected mass.

Results: H3R availability (V_T) was correlated with age but not BMI. V_T displayed a negative correlation with age in the anterior cingulate cortex (r = -0.61, p = 0.004), frontal cortex (r = -0.50, p = 0.020), olfactory cortex (r = -0.50, p = 0.022), parietal cortex (r = -0.58, p = 0.006), cerebellum cortex (r = -0.53, p = 0.013), insula (r = -0.48, p = 0.027), putamen (r = -0.46, p = 0.034), thalamus (r = -0.45, p = 0.038), and hippocampus (r = 0.45, p = 0.039).

Conclusion: This in vivo H3R study found a significant age-related decline in most cortical and subcortical regions.

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年龄和BMI对健康人组胺H3受体可用性的影响

目的：利用体内[11C]GSK189254正电子发射断层扫描（PET）成像评估健康人H3R可用性随年龄和体重指数（BMI）的变化。方法：24名健康个体（2名女性，22名男性，年龄20-47岁）使用[11C]GSK189254高分辨率研究断层扫描（HRRT）或HR +扫描仪进行扫描。使用双组织室模型计算区域VT（分布体积）值。检查VT与年龄、BMI之间的相关性，调整年龄或性别和注射肿块相关的潜在混淆效应。结果：H3R有效性（VT）与年龄相关，与BMI无关。VT在前扣带皮质（r = -0.61, p = 0.004）、额叶皮质（r = -0.50, p = 0.020）、嗅觉皮质（r = -0.50, p = 0.022）、顶叶皮质（r = -0.58, p = 0.006）、小脑皮质（r = -0.53, p = 0.013）、脑岛（r = -0.48, p = 0.027）、壳核（r = -0.46, p = 0.034）、丘脑（r = -0.45, p = 0.038）、海马（r = 0.45, p = 0.039）与年龄呈负相关。结论：这项体内H3R研究发现，大多数皮层和皮层下区域的H3R与年龄相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Imaging and Biology 医学-核医学

CiteScore

6.90

自引率

3.20%

发文量

审稿时长

3 months

期刊介绍： Molecular Imaging and Biology (MIB) invites original contributions (research articles, review articles, commentaries, etc.) on the utilization of molecular imaging (i.e., nuclear imaging, optical imaging, autoradiography and pathology, MRI, MPI, ultrasound imaging, radiomics/genomics etc.) to investigate questions related to biology and health. The objective of MIB is to provide a forum to the discovery of molecular mechanisms of disease through the use of imaging techniques. We aim to investigate the biological nature of disease in patients and establish new molecular imaging diagnostic and therapy procedures. Some areas that are covered are: Preclinical and clinical imaging of macromolecular targets (e.g., genes, receptors, enzymes) involved in significant biological processes. The design, characterization, and study of new molecular imaging probes and contrast agents for the functional interrogation of macromolecular targets. Development and evaluation of imaging systems including instrumentation, image reconstruction algorithms, image analysis, and display. Development of molecular assay approaches leading to quantification of the biological information obtained in molecular imaging. Study of in vivo animal models of disease for the development of new molecular diagnostics and therapeutics. Extension of in vitro and in vivo discoveries using disease models, into well designed clinical research investigations. Clinical molecular imaging involving clinical investigations, clinical trials and medical management or cost-effectiveness studies.