Time-Dependent Changes in the Skin Hardness in Taxane-Induced Swollen Arms.

IF 1.9 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Kotaro Suehiro, Saiko Honda, Takasuke Harada, Yuriko Takeuchi, Takahiro Mizoguchi, Ryunosuke Sakamoto, Ryo Suzuki, Hiroshi Kurazumi, Kimikazu Hamano
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Abstract

Background: We aimed to clarify the time-dependent changes in skin hardness in taxane-induced arm swelling. Methods and Results: Fifteen patients with unilateral arm swelling that developed during or within 3 months from the termination of postoperative taxane-containing chemotherapy were studied. The patients were followed up every 3-6 months for 24 months from the initial visit. During each visit, arm circumference and skin hardness were assessed using a scale ranging from 1 (softest) to 7 (hardest). Ultrasonography of the skin and subcutaneous tissues was performed at 0, 6, 12, and 24 months from the initial visit. In the initial visit, the mean skin hardness in the affected and contralateral arms was 3.8 versus 2.8 (p < 0.05) in the medial/lateral upper arm, 5.0 versus 2.8 (p < 0.01) in the medial forearm, and 4.3 versus 2.8 (p < 0.05) in the lateral forearm. In 12 patients whose arm swelling resolved, the difference in skin hardness between the arms disappeared in 9 patients until 9 months from the initial visit, whereas a mild difference in skin hardness persisted in the remaining 3 patients. Even in three patients whose arm swelling persisted, a certain improvement was observed until 9-12 months from the initial visit. Conclusions: We found that the majority of skin hardening associated with taxane-induced arm swelling improved until approximately 9-12 months from the initial visit, including complete resolution in 60% of patients.

紫杉烷诱导的肿胀手臂皮肤硬度随时间的变化。
背景:我们的目的是澄清紫杉烷引起的手臂肿胀中皮肤硬度的时间依赖性变化。方法与结果:对术后紫杉烷化疗结束后3个月内发生单侧手臂肿胀的患者15例进行研究。每3 ~ 6个月随访一次,随访24个月。在每次访问中,使用从1(最软)到7(最硬)的量表评估手臂围度和皮肤硬度。在首次就诊后的0、6、12和24个月分别对皮肤和皮下组织进行超声检查。初次就诊时,受累臂和对侧臂的平均皮肤硬度分别为3.8和2.8 (p < 0.05),上臂内侧和外侧为5.0和2.8 (p < 0.01),前臂外侧为4.3和2.8 (p < 0.05)。在12例手臂肿胀消退的患者中,9例患者的手臂之间的皮肤硬度差异在初次就诊9个月后消失,而其余3例患者的皮肤硬度存在轻微差异。即使在三个手臂肿胀持续存在的患者中,从初次就诊到9-12个月后,也观察到一定的改善。结论:我们发现大多数与紫杉烷诱导的手臂肿胀相关的皮肤硬化在初次就诊后大约9-12个月得到改善,包括60%的患者完全消退。
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来源期刊
Lymphatic research and biology
Lymphatic research and biology Medicine-Cardiology and Cardiovascular Medicine
CiteScore
3.10
自引率
7.10%
发文量
85
审稿时长
>12 weeks
期刊介绍: Lymphatic Research and Biology delivers the most current peer-reviewed advances and developments in lymphatic biology and pathology from the world’s leading biomedical investigators. The Journal provides original research from a broad range of investigative disciplines, including genetics, biochemistry and biophysics, cellular and molecular biology, physiology and pharmacology, anatomy, developmental biology, and pathology. Lymphatic Research and Biology coverage includes: -Vasculogenesis and angiogenesis -Genetics of lymphatic disorders -Human lymphatic disease, including lymphatic insufficiency and associated vascular anomalies -Physiology of intestinal fluid and protein balance -Immunosurveillance and immune cell trafficking -Tumor biology and metastasis -Pharmacology -Lymphatic imaging -Endothelial and smooth muscle cell biology -Inflammation, infection, and autoimmune disease
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