Resveratrol Alleviates Aflatoxin B1-induced Renal Cortex Oxidative Stress and Apoptosis in Adult Male Albino Rats.

IF 0.8 Q3 MEDICINE, GENERAL & INTERNAL
Naglaa A Bayomy, Reda H Elbakary, Nawal Salama Gouda, Marwa S Badawi, Saad Elshafey, Hanan A Elgendy, Awwad Alenezy, Safya E Esmaeel, Eslam K Fahmy, Naglaa Mokhtar
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引用次数: 0

Abstract

Background: Aflatoxin B1 (AFB1) is a mycotoxin generated by the fungi Aspergillus flavus and Aspergillus parasiticus, known for its potential to cause liver cancer and has been associated with several adverse health effects. It commonly contaminates cereals, peanuts, corn, and other crops, posing serious risks to both poultry and human health. One promising natural compound that has gained attention for its potential health benefits is resveratrol. The current research aims to explore the possible effect of resveratrol on AFB1-induced kidney damage in rats.

Materials and methods: Forty adult male albino rats were evenly assigned into four groups: a control group, a group treated with resveratrol at a dosage of 10 mg/kg/day orally for 10 days, a group treated with AFB1 at a dosage of 1.5 mg/kg/day orally for 10 days and a group treated with both resveratrol and AFB1. After 10 days of treatment, renal tissues were processed for biochemical, gene expression, histopathological, and immunohistochemical investigations.

Results: Administering resveratrol led to a reduction in serum creatinine, blood urea nitrogen, renal malondialdehyde concentrations, interleukin 6 gene expression, and the immunoreactivity of the proapoptotic protein (Bax). It also restored reduced glutathione levels, increased sirtuin 1 gene expression, and the immunoreactivity of the antiapoptotic protein (Bcl2). Furthermore, resveratrol improved the alterations in the histopathology in AFB1-treated group.

Conclusions: Coadministration of resveratrol in AFB1 toxicity exhibited a significant ability to improve renal function through antioxidant, anti-inflammatory, and antiapoptotic mechanisms in experimentally induced renal damage by AFB1.

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白藜芦醇减轻黄曲霉毒素b1诱导的成年雄性白化大鼠肾皮质氧化应激和细胞凋亡。
背景:黄曲霉毒素B1 (AFB1)是由真菌黄曲霉和寄生曲霉产生的一种霉菌毒素,以其可能导致肝癌而闻名,并与几种不良健康影响有关。它通常污染谷物、花生、玉米和其他作物,对家禽和人类健康构成严重风险。白藜芦醇是一种很有前途的天然化合物,因其潜在的健康益处而受到关注。本研究旨在探讨白藜芦醇对afb1所致大鼠肾损伤的可能影响。材料与方法:将40只成年雄性白化大鼠平均分为4组:对照组、白藜芦醇10mg /kg/d口服组、AFB1 1.5 mg/kg/d口服组、白藜芦醇和AFB1联合治疗组,连续10 d。治疗10天后,对肾组织进行生化、基因表达、组织病理学和免疫组织化学检查。结果:给予白藜芦醇导致血清肌酐、血尿素氮、肾丙二醛浓度、白细胞介素6基因表达和促凋亡蛋白(Bax)的免疫反应性降低。它还恢复了降低的谷胱甘肽水平,增加了sirtuin 1基因表达和抗凋亡蛋白(Bcl2)的免疫反应性。此外,白藜芦醇改善了afb1治疗组的组织病理学改变。结论:联合白藜芦醇治疗AFB1毒性可通过抗氧化、抗炎和抗凋亡机制显著改善AFB1实验性肾损伤的肾功能。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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