The expression and association of MATK in chronic hypoperfusion patients with white matter hyperintensity.

IF 4.5 2区医学 Q2 GERIATRICS & GERONTOLOGY

Frontiers in Aging Neuroscience Pub Date : 2025-08-26 eCollection Date: 2025-01-01 DOI:10.3389/fnagi.2025.1570482

Ming Zhao, Jiayue Zhang, Qianqian Yang, Lei Chen, Hongjian Shen, Yingyan Pu, Wei Wei, Yi Han, Ping Zhang

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Abstract

Background: Chronic cerebral hypoperfusion (CCH) is a key contributor to vascular cognitive impairment (VCI). Patients with CCH frequently exhibit white matter hyperintensities (WMH) on MRI. This study investigated the expression and clinical relevance of megakaryocyte-associated tyrosine kinase (MATK) in CCH patients with WMH.

Methods: We recruited 42 anterior circulation stenosis patients with CCH and WMH (CCH-WMH group) and 45 age-matched healthy controls. MATK mRNA expression in peripheral blood mononuclear cells (PBMCs) was quantified using qPCR. WMH severity was graded using the Fazekas scale. Correlations between MATK expression and imaging/clinical parameters were analyzed using Pearson's correlation and logistic regression. Diagnostic performance was assessed via ROC analysis.

Results: Megakaryocyte-associated tyrosine kinase expression was significantly downregulated in the CCH-WMH group versus controls (1.20 ± 0.99 vs. 1.84 ± 0.87; P < 0.01). MATK levels showed a strong negative correlation with Fazekas scores (R² = 0.3405, P < 0.001). Multivariate regression identified MATK as independently associated with WMH (aOR = 0.492; 95% CI: 0.262-0.923; P = 0.027). ROC analysis demonstrated moderate diagnostic accuracy for WMH (AUC = 0.743; 95% CI: 0.637-0.849).

Conclusion: Reduced peripheral MATK expression correlates with WMH severity in CCH patients and may serve as a potential diagnostic biomarker.

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MATK在慢性低灌注伴白质高信号患者中的表达及相关性研究。

背景：慢性脑灌注不足（CCH）是血管性认知障碍（VCI）的重要诱因。CCH患者在MRI上经常表现为白质高信号（WMH）。本研究探讨巨核细胞相关酪氨酸激酶（MATK）在CCH合并WMH患者中的表达及其临床意义。方法：我们招募42例CCH和WMH前循环狭窄患者（CCH-WMH组）和45例年龄匹配的健康对照。采用qPCR方法定量外周血单个核细胞（PBMCs）中MATK mRNA的表达。采用Fazekas量表对WMH严重程度进行分级。采用Pearson相关和logistic回归分析MATK表达与影像学/临床参数的相关性。通过ROC分析评估诊断表现。结果：CCH-WMH组巨核细胞相关酪氨酸激酶表达明显下调（1.20±0.99∶1.84±0.87;P < 0.01）。MATK水平与Fazekas评分呈显著负相关（R2 = 0.3405, P < 0.001）。多因素回归发现MATK与WMH独立相关（aOR = 0.492; 95% CI: 0.262-0.923; P = 0.027）。ROC分析显示WMH的诊断准确度中等（AUC = 0.743; 95% CI: 0.637-0.849）。结论：外周MATK表达降低与CCH患者WMH严重程度相关，可能是一种潜在的诊断生物标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Aging Neuroscience GERIATRICS & GERONTOLOGY-NEUROSCIENCES

CiteScore

6.30

自引率

8.30%

发文量

1426

期刊介绍： Frontiers in Aging Neuroscience is a leading journal in its field, publishing rigorously peer-reviewed research that advances our understanding of the mechanisms of Central Nervous System aging and age-related neural diseases. Specialty Chief Editor Thomas Wisniewski at the New York University School of Medicine is supported by an outstanding Editorial Board of international researchers. This multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide.