Herbal drug delivery for ocular treatments—an updated review

IF 2.7 2区医学 Q1 OPHTHALMOLOGY

Experimental eye research Pub Date : 2025-09-09 DOI:10.1016/j.exer.2025.110629

Heybet Kerem Polat , Emre Tunçel , Sefa Gözcü , Yasin Turanlı , Nasıf Fatih Karakuyu , Sedat Ünal

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引用次数: 0

Abstract

The aim of this review is to address the challenges faced by traditional dosage forms in ocular herbal drug delivery and to demonstrate the potential offered by nanotechnology to overcome related challenges. This study employed a systematic investigation approach, focusing on nanocarrier systems and advanced material-based strategies documented in the literature. Various nanoformulation systems, including in situ gels, liposomes, ethosomes, transfersomes, exosomes, polymeric and lipid-based nanoparticles, emulsions, nanofibers, and dendrimers, are extensively evaluated. The contribution of innovative nanomaterials, such as nanozymes and metallic and ceramic nanoparticles, to herbal drug delivery is assessed. Different herbal secondary metabolites with potential indications for ocular diseases are reviewed. The reported findings in the literature demonstrate that nanotechnology can enhance the solubility and stability of plant-derived active ingredients, enabling controlled release in target tissues and thus enhancing therapeutic efficacy. Furthermore, safety, toxicity, and regulatory frameworks are scrutinized. In summary, this review highlights the opportunities offered by nanotechnology-based systems in herbal medicine applications and guides integrating of alternative herbal therapies with allopathic approaches in the future.

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眼部治疗中草药给药——最新综述。

这篇综述的目的是解决传统剂型在眼部给药中所面临的挑战，并展示纳米技术克服相关挑战的潜力。本研究采用了系统的调查方法，重点关注纳米载体系统和文献中记载的先进的基于材料的策略。各种纳米制剂系统，包括原位凝胶、脂质体、脂质体、转移体、外泌体、聚合物和脂基纳米颗粒、乳液、纳米纤维和树状大分子，都被广泛评估。评估了创新纳米材料，如纳米酶、金属和陶瓷纳米颗粒，对草药药物递送的贡献。不同的草药次生代谢物与潜在适应症的眼部疾病进行审查。文献报道的研究结果表明，纳米技术可以提高植物源性活性成分的溶解度和稳定性，使其在靶组织中可控释放，从而提高治疗效果。此外，安全性，毒性和监管框架进行了仔细审查。总之，这篇综述强调了基于纳米技术的系统在草药应用中提供的机会，并指导未来将替代草药疗法与对抗疗法相结合。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Experimental eye research 医学-眼科学

CiteScore

6.80

自引率

5.90%

发文量

323

审稿时长

66 days

期刊介绍： The primary goal of Experimental Eye Research is to publish original research papers on all aspects of experimental biology of the eye and ocular tissues that seek to define the mechanisms of normal function and/or disease. Studies of ocular tissues that encompass the disciplines of cell biology, developmental biology, genetics, molecular biology, physiology, biochemistry, biophysics, immunology or microbiology are most welcomed. Manuscripts that are purely clinical or in a surgical area of ophthalmology are not appropriate for submission to Experimental Eye Research and if received will be returned without review.