The Association between Fasting Remnant Cholesterol and White Matter Hyperintensities in Acute Ischemic Stroke Patients.

IF 1.5 3区医学 Q3 CLINICAL NEUROLOGY

Cerebrovascular Diseases Pub Date : 2025-09-11 DOI:10.1159/000548406

Qi-Wei Yu, Ru-Yang Zhang, Xin-Qi Yan, Hua Zhou, Qian Feng

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引用次数: 0

Abstract

Introduction: This study aims to examine the correlation between fasting remnant cholesterol (RC) levels and white matter hyperintensities (WMHs) in patients diagnosed with acute ischemic stroke (AIS).

Methods: Patients diagnosed with AIS were enrolled from the Department of Neurology at the affiliated Suzhou Hospital of Nanjing Medical University. The burden of WMHs was evaluated using the Fazekas scale on magnetic resonance imaging. RC was calculated as total cholesterol (TC) - high-density lipoprotein cholesterol (HDL-C) - low-density lipoprotein cholesterol (LDL-C). WMHs severity was categorized using Fazekas scores: low WMHs (0-3 points) and high WMHs (≥4 points). The relationship between RC levels and the burden of WMHs was examined through multivariate logistic regression and restricted cubic spline (RCS) logistic regression analyses. Finally, subgroup analyses were performed.

Results: A total of 650 patients with AIS were included in this study. The RC levels in the low-WMHs group were significantly higher than those in the high-WMHs group (t = 3.45, p < 0.05). When RC was treated as a continuous variable for logistic regression analysis, in fully adjusted models, there was a negative correlation between RC and WMHs scores (OR: 0.314, 95% CI: 0.143-0.685, p < 0.05). When RC was categorized, in fully adjusted models, there was a significant inverse association was observed in the highest RC quartile compared with the lowest (OR: 0.598, 95% CI: 0.372-0.961, p < 0.05). Using RCS analysis, when RC was ≥0.57 mmol/L, there was a negative correlation between RC and WMHs scores (OR: 0.179, 95% CI: 0.04-0.554, p < 0.05), and as RC values increased, the WMHs scores decreased. In subgroup analysis, there was a negative correlation between RC and WMHs, especially in males.

Conclusion: This study suggests that maintaining RC levels of ≥0.57 mmol/L during the acute phase of AIS may be associated with a reduction in WMHs burden, particularly among males. However, further prospective trials are required to validate its safety and efficacy.

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急性缺血性脑卒中患者空腹残余胆固醇与白质高信号的关系。

目的：本研究旨在探讨急性缺血性脑卒中（AIS）患者空腹残余胆固醇（RC）水平与白质高信号（WMHs）的相关性。方法：选取南京医科大学附属苏州医院神经内科诊断为AIS的患者。采用Fazekas核磁共振评分法（MRI）评价医院负担。RC计算为总胆固醇(TC) -高密度脂蛋白胆固醇(HDL-C) -低密度脂蛋白胆固醇（LDL-C）。使用Fazekas评分对wmh的严重程度进行分类：低wmh（0-3分）和高wmh（≥4分）。通过多变量logistic回归和限制性三次样条（RCS） logistic回归分析，探讨RC水平与wmh负担之间的关系。最后进行亚组分析。结果：本研究共纳入650例AIS患者。低wmh组的RC水平显著高于高wmh组（t=3.45， P）。结论：本研究提示，在AIS急性期维持≥0.57 mmol/L的RC水平可能与减轻wmh负担有关，尤其是在男性中。然而，需要进一步的前瞻性试验来验证其安全性和有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cerebrovascular Diseases 医学-临床神经学

CiteScore

4.50

自引率

0.00%

发文量

审稿时长

1 months

期刊介绍： A rapidly-growing field, stroke and cerebrovascular research is unique in that it involves a variety of specialties such as neurology, internal medicine, surgery, radiology, epidemiology, cardiology, hematology, psychology and rehabilitation. ''Cerebrovascular Diseases'' is an international forum which meets the growing need for sophisticated, up-to-date scientific information on clinical data, diagnostic testing, and therapeutic issues, dealing with all aspects of stroke and cerebrovascular diseases. It contains original contributions, reviews of selected topics and clinical investigative studies, recent meeting reports and work-in-progress as well as discussions on controversial issues. All aspects related to clinical advances are considered, while purely experimental work appears if directly relevant to clinical issues.