Sensitization to common food allergens in infants with food protein-induced allergic proctocolitis: A prospective study.

IF 2.1 Q3 ALLERGY

Asia Pacific Allergy Pub Date : 2025-09-01 Epub Date: 2025-03-17 DOI:10.5415/apallergy.0000000000000182

Mozhgan Moghtaderi, Sara Mostafavi, Naser Honar, Khadijehsadat Najib, Seyed Hesamedin Nabavizadeh

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Abstract

Background: Food protein-induced allergic proctocolitis (FPIAP) is a non-IgE-associated disease, although some evidence exhibits IgE sensitization in a minority of patients.

Objectives: This study aimed to determine the prevalence of IgE sensitization to common foods using skin tests and assess milk outgrowing in infants with FPIAP over a 5-year follow-up period.

Methods: This prospective study included infants with FPIAP in 2017. Skin prick tests were done using commercial extracts of 11 common food allergens. Infants were followed for 5 years, and the resolution was established by successfully ingesting cow's milk.

Results: Of 126 infants analyzed, 81 infants (40 boys and 41 girls) with FPIAP completed this study. The frequency of food sensitization was 32% to at least one of the applied food allergens. Cow's milk (13.6%), egg (13.6%), and beef (6.2%) were the most frequent allergens, respectively. In this study, 45.7% of the infants developed a tolerance to the milk by the age of 1 year, 77.1% by the age of 2, 91.3% by the age of 3, and 96.3% by the age of 4. The rate of sensitization to milk was significantly different based on the tolerance time of early onset and grated late start for cow's milk (P < 0.001).

Conclusion: This study suggests pointing out skin tests of infants with FPIAP for common food allergens because IgE-mediated sensitization can infer a greater chance of a persistent course of milk intolerance.

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食物蛋白诱发的过敏性直结肠炎婴儿对常见食物过敏原的致敏：一项前瞻性研究。

背景：食物蛋白诱导的过敏性直结肠炎（FPIAP）是一种与IgE无关的疾病，尽管一些证据显示在少数患者中存在IgE致敏。目的：本研究旨在通过皮肤试验确定常见食物的IgE致敏率，并在5年随访期间评估FPIAP婴儿的乳汁生长情况。方法：本前瞻性研究纳入2017年FPIAP患儿。皮肤点刺试验使用11种常见食物过敏原的商业提取物进行。对婴儿进行了5年的跟踪研究，通过成功地摄入牛奶来建立解决方案。结果：在126名被分析的婴儿中，81名患有FPIAP的婴儿（40名男孩和41名女孩）完成了这项研究。对至少一种应用的食物过敏原，食物致敏的频率为32%。牛奶（13.6%）、鸡蛋（13.6%）和牛肉（6.2%）分别是最常见的过敏原。在这项研究中，45.7%的婴儿在1岁时对牛奶产生耐受，77.1%的婴儿在2岁时产生耐受，91.3%的婴儿在3岁时产生耐受，96.3%的婴儿在4岁时产生耐受。不同耐受时间的奶牛对牛奶的致敏率差异有统计学意义（P < 0.001）。结论：本研究建议对患有FPIAP的婴儿进行常见食物过敏原的皮肤试验，因为ige介导的致敏可以推断出更大的持续牛奶不耐受过程的可能性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asia Pacific Allergy ALLERGY-

CiteScore

2.50

自引率

5.90%

发文量

期刊介绍： Asia Pacific Allergy (AP Allergy) is the official journal of the Asia Pacific Association of Allergy, Asthma and Clinical Immunology (APAAACI). Although the primary aim of the journal is to promote communication between Asia Pacific scientists who are interested in allergy, asthma, and clinical immunology including immunodeficiency, the journal is intended to be available worldwide. To enable scientists and clinicians from emerging societies appreciate the scope and intent of the journal, early issues will contain more educational review material. For better communication and understanding, it will include rational concepts related to the diagnosis and management of asthma and other immunological conditions. Over time, the journal will increase the number of original research papers to become the foremost citation journal for allergy and clinical immunology information of the Asia Pacific in the future.