Epigenetic Changes Related to Hypertension in Asian Adults: A Systematic Review

Q1 Medicine

Chronic Diseases and Translational Medicine Pub Date : 2025-05-13 DOI:10.1002/cdt3.70008

Lilik Sukesi, Yunia Sribudiani, Steven Yulius Usman, Eric Ricardo Yonatan, Ahmedz Widiasta, Noormarina Indraswari, Ria Bandiara, Nanny N. M. Soetedjo

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引用次数: 0

Abstract

Background

Elevated high blood pressure is controlled by complicated, little-understood genetic and epigenetic pathways that are influenced by both heritable and environmental variables. Many adult systolic and diastolic blood pressure-related genomic loci have been identified through previous genome-wide association studies (GWAS); meanwhile, studies specifically on Asian adult populations have not been done. This study aims to comprehensively assess and summarize any gene changes that have been studied and see whether there is a possible influence between epigenetic changes and hypertension in Asian adults.

Methods

This evidence-based analysis is based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) 2020 statement and has been registered in PROSPERO under registration number [CRD42024622261]. The data were processed qualitatively to assess the risk of bias using the Newcastle–Ottawa Scale (NOS) and Agency for Health Research and Quality (AHRQ) standards as the threshold. Our study in particular shows that epigenetic modifications may play a role in hypertension, particularly in Asian individuals.

Results

A total of 28 studies were selected for qualitative evaluation. In the adult Asian population, 26 publications (92.8%) reported a relationship between blood pressure and epigenetics. Every study describes a distinct gene or location associated with hypo- or hypermethylation. Elevated systolic and diastolic blood pressure was linked to variations of several single-nucleotide polymorphisms (SNPs), cytosine phosphate guanines (CPGs), and other monogenic genes.

Conclusion

Alterations in epigenetic modifications in potential genes or loci are linked to systolic and diastolic blood pressure of Asian adult populations.

PROSPERO Protocol Registration: CRD42024622261.

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亚洲成年人高血压相关的表观遗传改变：系统综述

背景：高血压是由复杂的、鲜为人知的遗传和表观遗传途径控制的，这些途径受遗传和环境变量的影响。许多成人收缩压和舒张压相关的基因组位点已经通过先前的全基因组关联研究（GWAS）确定；同时，还没有专门针对亚洲成年人的研究。本研究旨在对已研究的基因变化进行综合评估和总结，探讨表观遗传变化与亚洲成人高血压之间是否存在可能的影响。该循证分析基于系统评价和荟萃分析首选报告项目（PRISMA） 2020声明，并已在PROSPERO注册，注册号为[CRD42024622261]。对数据进行定性处理，以纽卡斯尔-渥太华量表（NOS）和健康研究与质量机构（AHRQ）标准为阈值评估偏倚风险。我们的研究特别表明，表观遗传修饰可能在高血压中起作用，特别是在亚洲个体中。结果共选取28项研究进行定性评价。在成年亚洲人群中，26篇出版物（92.8%）报道了血压与表观遗传学之间的关系。每项研究都描述了与低甲基化或高甲基化相关的不同基因或位置。收缩压和舒张压升高与几种单核苷酸多态性（snp）、磷酸胞嘧啶鸟嘌呤（CPGs）和其他单基因基因的变异有关。结论亚洲成年人的收缩压和舒张压与潜在基因或基因座的表观遗传修饰改变有关。普洛斯佩罗协议注册号：CRD42024622261。

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来源期刊

Chronic Diseases and Translational Medicine Medicine-General Medicine

CiteScore

6.70

自引率

0.00%

发文量

195

审稿时长

35 weeks

期刊介绍： This journal aims to promote progress from basic research to clinical practice and to provide a forum for communication among basic, translational, and clinical research practitioners and physicians from all relevant disciplines. Chronic diseases such as cardiovascular diseases, cancer, diabetes, stroke, chronic respiratory diseases (such as asthma and COPD), chronic kidney diseases, and related translational research. Topics of interest for Chronic Diseases and Translational Medicine include Research and commentary on models of chronic diseases with significant implications for disease diagnosis and treatment Investigative studies of human biology with an emphasis on disease Perspectives and reviews on research topics that discuss the implications of findings from the viewpoints of basic science and clinical practic.