Identifying Adherence Trajectories in Chronic Hepatitis B: A Cluster-Based Approach to Long-Term Treatment Management

IF 2.3 3区 医学 Q2 GASTROENTEROLOGY & HEPATOLOGY
Lin Zhang, Huichun Ji, Suhua Pang, Youde Yan, Zhenjiang Zhang
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引用次数: 0

Abstract

This study aimed to investigate the levels and longitudinal trajectories of medication adherence among patients with chronic hepatitis B (CHB), identify key psychosocial factors influencing adherence and provide evidence to inform strategies for optimising long-term treatment and enhancing patients' quality of life. A longitudinal study was conducted among CHB patients, 305 completing a 12-month follow-up. Medication adherence and psychosocial data were collected at baseline and at 3, 6, 9 and 12 months. K-means cluster analysis was performed to identify distinct adherence patterns, and differences in psychosocial characteristics across clusters were analysed. Four adherence trajectories were identified: improvement, low adherence, decline and high adherence. Significant differences were observed among the groups in terms of medication adherence scores and psychosocial factors (p < 0.05). Higher adherence was positively correlated with self-efficacy and social support, while lower adherence was associated with higher levels of perceived stigma and depression. Medication adherence among CHB patients exhibits distinct dynamic patterns, strongly influenced by psychosocial factors. Targeted interventions focusing on psychological support, stigma reduction and strengthening social support networks may improve adherence and ultimately enhance the quality of life for patients with chronic hepatitis B.

确定慢性乙型肝炎的依从性轨迹:一种基于集群的长期治疗管理方法
本研究旨在调查慢性乙型肝炎(CHB)患者的药物依从性水平和纵向轨迹,确定影响依从性的关键社会心理因素,并为优化长期治疗和提高患者生活质量提供证据。在CHB患者中进行了一项纵向研究,305名患者完成了12个月的随访。在基线和3、6、9和12个月时收集药物依从性和社会心理数据。进行k均值聚类分析以确定不同的依从模式,并分析聚类之间的社会心理特征差异。确定了四种依从性轨迹:改善、低依从性、下降和高依从性。各组间药物依从性评分及心理社会因素差异有统计学意义(p < 0.05)。较高的依从性与自我效能感和社会支持呈正相关,而较低的依从性与较高的耻辱感和抑郁水平相关。慢性乙型肝炎患者的药物依从性表现出明显的动态模式,受到社会心理因素的强烈影响。以心理支持、减少耻辱感和加强社会支持网络为重点的有针对性的干预措施可能会改善慢性乙型肝炎患者的依从性,并最终提高其生活质量。
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来源期刊
Journal of Viral Hepatitis
Journal of Viral Hepatitis 医学-病毒学
CiteScore
6.00
自引率
8.00%
发文量
138
审稿时长
1.5 months
期刊介绍: The Journal of Viral Hepatitis publishes reviews, original work (full papers) and short, rapid communications in the area of viral hepatitis. It solicits these articles from epidemiologists, clinicians, pathologists, virologists and specialists in transfusion medicine working in the field, thereby bringing together in a single journal the important issues in this expanding speciality. The Journal of Viral Hepatitis is a monthly journal, publishing reviews, original work (full papers) and short rapid communications in the area of viral hepatitis. It brings together in a single journal important issues in this rapidly expanding speciality including articles from: virologists; epidemiologists; clinicians; pathologists; specialists in transfusion medicine.
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