Ruthenium complexes comprising nitrogen donor ligands: synthesis and investigation of their cytotoxicity potential

IF 1.7 4区化学 Q3 CHEMISTRY, INORGANIC & NUCLEAR

Transition Metal Chemistry Pub Date : 2025-05-02 DOI:10.1007/s11243-025-00654-6

Lathewdeipor Shadap, Charlestine Soh, Smarling Suting, Mayuri Bhattacharyya, Baphilinia Jones Mylliemngap, Suktilang Majaw, Werner Kaminsky, Kenneth Umdor, Cheerfulman Masharing, Badaker M. Laloo, Barisha Wahlang, Matbiangthew Shadap, Evergreen K. Rymmai

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Abstract

Complexes (1–3) with nitrogen-based heterocyclic ligands were synthesized by reacting ruthenium precursor [Ru(η⁶-p-cymene)(μ-Cl)Cl]₂ and ligands L1, L2 and L3. Upon reacting the complexes 1–3 with sodium azide, azido complexes 4–6 were obtained. These complexes as well as ligands were tested for anti-cancer activity where, ligand L2 was found to have lowest IC₅₀ value with stable interaction of ROCK-1 protein suggesting one of the possible mechanisms for complex’s anti-cancer activity.

Graphical Abstract

Half-sandwich ruthenium complexes 1–3 were synthesized and upon further reaction with sodium azide (NaN3) in methanol yielded azido ruthenium complexes 4–6. All the ligands and complexes were studied for anticancer activity. Anticancer activity assessed in human lung cancer cell line (A549) revealed that ligand L2 has the highest anti-cancer activity amongst the others studied.

Azido Ruthenium Complex 4

Abstract Image

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含氮供体配体的钌配合物：合成及其细胞毒性潜力的研究

以钌前体[Ru（η - 6-对伞花烃）（μ-Cl）Cl]2与配体L1、L2和L3反应，合成了氮基杂环配体配合物（1-3）。配合物1-3与叠氮化钠反应后，得到叠氮配合物4-6。对这些复合物和配体进行了抗癌活性测试，发现配体L2的IC50值最低，与ROCK-1蛋白的相互作用稳定，这可能是复合物抗癌活性的机制之一。图摘要：合成了半夹层钌配合物1-3，并与叠氮化钠（NaN3）在甲醇中进一步反应得到叠氮钌配合物4-6。研究了所有配体和配合物的抗癌活性。对人肺癌细胞系（A549）的抗癌活性评估表明，在所有研究中，配体L2具有最高的抗癌活性。叠氮钌配合物

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来源期刊

Transition Metal Chemistry 化学-无机化学与核化学

CiteScore

3.60

自引率

0.00%

发文量

审稿时长

1.3 months

期刊介绍： Transition Metal Chemistry is an international journal designed to deal with all aspects of the subject embodied in the title: the preparation of transition metal-based molecular compounds of all kinds (including complexes of the Group 12 elements), their structural, physical, kinetic, catalytic and biological properties, their use in chemical synthesis as well as their application in the widest context, their role in naturally occurring systems etc. Manuscripts submitted to the journal should be of broad appeal to the readership and for this reason, papers which are confined to more specialised studies such as the measurement of solution phase equilibria or thermal decomposition studies, or papers which include extensive material on f-block elements, or papers dealing with non-molecular materials, will not normally be considered for publication. Work describing new ligands or coordination geometries must provide sufficient evidence for the confident assignment of structural formulae; this will usually take the form of one or more X-ray crystal structures.