Micro elastofluidic liquid diode for programmable unidirectional flow control

IF 5.4 2区 工程技术 Q1 BIOCHEMICAL RESEARCH METHODS
Lab on a Chip Pub Date : 2025-09-11 DOI:10.1039/D5LC00438A
Haotian Cha, Fariba Malekpour Galogahi, Quang Thang Trinh, Sharda Yadav, Jun Zhang, Hongjie An, Qin Li and Nam-Trung Nguyen
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引用次数: 0

Abstract

Controllable liquid transport is essential for fluid regulation in wearable biosensing platforms. Particularly, unidirectional flow offers a passive, geometry-dependent strategy to direct liquid movement without external actuation. However, most previous studies have focused solely on achieving unidirectional flow, with limited exploration of real-time tunability or reconfigurability. Here, we present a tuneable open-channel microfluidic platform featuring a chevron–ratchet geometry that enables passive and reversible liquid diode behaviour. Flow directionality and velocity are dynamically modulated through surface wettability tuning and mechanical stretching. A theoretical force model was first established to describe asymmetrical spreading, governed by Laplace pressure gradients and geometric curvature. Numerical simulations based on energy-minimization principles further elucidated wetting behaviour on structured surfaces. Concurrently, experimental validation confirmed three distinct flow regimes—pinned, unidirectional, and bidirectional—controlled by plasma-induced wettability modulation and applied mechanical strain. Stretching the channels along orthogonal axes led to programmable switching of flow states and geometry-sensitive pinning thresholds. We further integrated a hydrogel film as a sweat-acquisition interface and demonstrated sustained unidirectional transport under physiologically relevant inflow. This proof-of-concept validation complements the fundamental findings and highlights the translational potential of our open-channel platform as a simple, tuneable, and pumpless approach for wearable diagnostics, adaptive liquid routing, and flexible microfluidic circuitry.

Abstract Image

用于可编程单向流量控制的微弹性流体二极管
可控制的液体输送是可穿戴生物传感平台流体调节的关键。特别是,单向流提供了一种被动的、几何依赖的策略,可以在没有外部驱动的情况下指导液体运动。然而,以往的研究大多集中在实现单向流动上,对实时可调性或可重构性的探索有限。在这里,我们提出了一个可调谐的开放通道微流控平台,具有锯齿形棘轮几何形状,可以实现被动和可逆的液体二极管行为。流动方向和速度通过表面润湿性调节和机械拉伸进行动态调节。首先建立了一个理论力模型来描述由拉普拉斯压力梯度和几何曲率控制的不对称扩散。基于能量最小化原理的数值模拟进一步阐明了结构表面的润湿行为。同时,实验验证证实了等离子体诱导的润湿性调节和施加的机械应变控制的三种不同的流动模式——固定、单向和双向。沿着正交轴拉伸通道导致流动状态的可编程切换和几何敏感的钉住阈值。值得注意的是,由于应变触发的微裂缝和局部润湿性对比,y轴伸长导致了可逆的流体横向再分布。这项工作为构建无源流体逻辑元件提供了一种简单、可调谐和无泵的方法,在可穿戴诊断、自适应液体路由和柔性微流体电路中具有潜在的应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Lab on a Chip
Lab on a Chip 工程技术-化学综合
CiteScore
11.10
自引率
8.20%
发文量
434
审稿时长
2.6 months
期刊介绍: Lab on a Chip is the premiere journal that publishes cutting-edge research in the field of miniaturization. By their very nature, microfluidic/nanofluidic/miniaturized systems are at the intersection of disciplines, spanning fundamental research to high-end application, which is reflected by the broad readership of the journal. Lab on a Chip publishes two types of papers on original research: full-length research papers and communications. Papers should demonstrate innovations, which can come from technical advancements or applications addressing pressing needs in globally important areas. The journal also publishes Comments, Reviews, and Perspectives.
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