COMPARING THE EFFICACY OF VELSCOPE WITH VITAL STAINS IN THE DIAGNOSIS OF (COMMON)ORAL POTENTIALLY MALIGNANT DISORDERS AN OBSERVATIONAL STUDY.

IF 2 3区医学 Q2 Dentistry

Journal of Stomatology Oral and Maxillofacial Surgery Pub Date : 2025-09-08 DOI:10.1016/j.jormas.2025.102542

Dr Ramesh Tatapudi, Dr N Sowmya Vimala, Ravikanth Manyam, Dr Pravallika G, Dr B Ananda Babu, Dr M Veera Kumari, Dr Ujwala Sahithi N

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引用次数: 0

Abstract

Objective: Oral potentially malignant disorders (OPMDs) are a diverse group of oral mucosal lesions that carry an increased risk of malignant transformation. Although biopsy is the gold standard for the diagnosis of these lesions, early detection is crucial, emphasizing the need to introduce more reliable non-invasive screening modalities. The aim of the study was to compare the efficacy of VELscope and vital tissue staining techniques as screening tools in the detection of early dysplastic changes in OPMDS, such as oral leukoplakia (OL), oral lichen planus (OLP) & oral submucous fibrosis (OSMF) with histopathological confirmation.

Study design: Thirty patients clinically diagnosed as OL, OLP and OSMF were included in the study. All patients were subjected to VELscope examination, followed by vital tissue staining procedures. Lesions that were noted as positive by these techniques were evaluated and a biopsy site was selected and performed. Histopathological findings were recorded as either the presence or absence of dysplasia.

Results: Among 30 participants, histopathology revealed dysplasia in 83.3% of cases. For OL, VELscope showed the highest diagnostic utility (AUC = 0.458), though with limited sensitivity and specificity. In OLP, toluidine blue (AUC = 0.524) was closest to histopathology because of its high positive predictive value. In OSMF, VELscope demonstrated 100% sensitivity in comparison to other tests, but its low specificity & negative predictive value limited its reliability. Overall, none of the diagnostic adjuvants were independently reliable compared with histopathology.

Conclusion: VELscope showed comparatively better utility for oral leukoplakia and OSMF, while toluidine blue performed slightly better in oral lichen planus due to its positive predictive values. None of these diagnostic tools can be used as a standalone diagnostic method due to their specificity & negative predictive values. They may be used as supportive aids in guiding biopsy site selection, but histopathology remains the gold standard for definitive diagnosis.

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比较velscope和vital染色在（常见）口腔潜在恶性疾病诊断中的疗效：一项观察性研究。

目的：口腔潜在恶性疾病（OPMDs）是一组不同的口腔黏膜病变，其恶性转化的风险增加。虽然活检是诊断这些病变的金标准，但早期发现至关重要，强调需要引入更可靠的非侵入性筛查方式。该研究的目的是比较VELscope和活体组织染色技术作为筛查工具检测OPMDS早期发育不良变化的疗效，如口腔白斑（OL）、口腔扁平苔藓（OLP）和口腔黏膜下纤维化（OSMF），并进行组织病理学证实。研究设计：将30例临床诊断为OL、OLP和OSMF的患者纳入研究。所有患者均接受VELscope检查，随后进行重要组织染色。对这些技术检测为阳性的病变进行评估，选择活检部位并进行活检。组织病理学结果记录为存在或不存在不典型增生。结果：在30名参与者中，组织病理学检查显示83.3%的病例发育不良。对于OL， VELscope显示出最高的诊断效用（AUC = 0.458），尽管具有有限的敏感性和特异性。在OLP中，甲苯胺蓝（AUC = 0.524）具有较高的阳性预测值，与组织病理学最接近。在OSMF中，VELscope与其他检测相比具有100%的敏感性，但其低特异性和阴性预测值限制了其可靠性。总的来说，与组织病理学相比，没有一种诊断辅助剂是独立可靠的。结论：VELscope对口腔白斑和OSMF的预测效果较好，而甲苯胺蓝对口腔扁平苔藓的预测效果略好，具有阳性的预测价值。由于这些诊断工具的特异性和阴性预测值，它们都不能作为独立的诊断方法使用。它们可以作为指导活检部位选择的辅助工具，但组织病理学仍然是明确诊断的金标准。

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来源期刊

Journal of Stomatology Oral and Maxillofacial Surgery Dentistry-Oral Surgery

CiteScore

2.20

自引率

9.10%

发文量

305

期刊介绍： J Stomatol Oral Maxillofac Surg publishes research papers and techniques - (guest) editorials, original articles, reviews, technical notes, case reports, images, letters to the editor, guidelines - dedicated to enhancing surgical expertise in all fields relevant to oral and maxillofacial surgery: from plastic and reconstructive surgery of the face, oral surgery and medicine, … to dentofacial and maxillofacial orthopedics. Original articles include clinical or laboratory investigations and clinical or equipment reports. Reviews include narrative reviews, systematic reviews and meta-analyses. All manuscripts submitted to the journal are subjected to peer review by international experts, and must: Be written in excellent English, clear and easy to understand, precise and concise; Bring new, interesting, valid information - and improve clinical care or guide future research; Be solely the work of the author(s) stated; Not have been previously published elsewhere and not be under consideration by another journal; Be in accordance with the journal''s Guide for Authors'' instructions: manuscripts that fail to comply with these rules may be returned to the authors without being reviewed. Under no circumstances does the journal guarantee publication before the editorial board makes its final decision. The journal is indexed in the main international databases and is accessible worldwide through the ScienceDirect and ClinicalKey Platforms.