Valvular Heart Failure as a Distinct Group in Acute Decompensated Heart Failure.

IF 1.3 4区 医学 Q2 MEDICINE, GENERAL & INTERNAL
Israel Medical Association Journal Pub Date : 2025-09-01
Assi Milwidsky, Omar Saeed, Amrita Balgobind, Rachel Clark, Francesco Castagna, Shivank Madan, Yan Topilsky, Edwin C Ho, Azeem Latib, Ulrich P Jorde
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引用次数: 0

Abstract

Background: Functional mitral and tricuspid regurgitation (fMR and fTR, respectively) portend increased morbidity and mortality among heart failure (HF) patients.

Objectives: To characterize acute decompensated valvular HF (VHF) as a novel HF category, defined by presence of either more than moderate fTR or more than moderate fMR with left ventricular ejection fraction (LVEF) ≤ 50%.

Methods: Patients with VHF were prospectively enrolled over a 6-month period and compared to acute decompensated heart failure (ADHF) patients without significant fTR or fMR. We used a standardized diuretic protocol when indicated, and appropriate inpatient guideline-directed medical therapy was initiated.

Results: Among 322 patients admitted with ADHF, 83 (26%) met VHF criteria with mean age 66 ± 13 years, 43 (52%) males, and median LVEF of 30% (20-55). Of 61 patients in whom the diuretic protocol was initiated, 59 (97%) had an adequate response (i.e., > 100 cc/hour for at least 6 hours). VHF patients had longer length of hospitalization (8 [5-13] vs. 5 [3-8] days, P < 0.001), and higher rates of 90-day heart replacement therapy (HRT) or death (hazard ratio 2.52, 95% confidence interval (1.13-5.64); P = 0.024).

Conclusions: Over a quarter of ADHF patients can be newly categorized as VHF patients, distinguished by prolonged hospitalization and worse 90-day mortality / HRT rate. The initial response rate to a standardized diuretic protocol was high.

急性失代偿性心力衰竭中瓣膜性心力衰竭的独特组。
背景:功能性二尖瓣和三尖瓣反流(分别为fMR和fTR)预示着心力衰竭(HF)患者发病率和死亡率的增加。目的:将急性失代偿性瓣膜性HF (VHF)定性为一种新的HF类别,定义为存在中度以上fTR或中度以上fMR且左室射血分数(LVEF)≤50%。方法:在6个月的时间里,VHF患者被前瞻性地纳入研究,并与没有明显fTR或fMR的急性失代偿性心力衰竭(ADHF)患者进行比较。当有指征时,我们使用标准化的利尿剂方案,并开始适当的住院指导药物治疗。结果:322例ADHF患者中,83例(26%)符合VHF标准,平均年龄66±13岁,男性43例(52%),中位LVEF为30%(20-55岁)。在61例开始使用利尿剂方案的患者中,59例(97%)有足够的反应(即bbb100 cc/小时至少6小时)。VHF患者住院时间更长(8[5-13]天和5[3-8]天,P < 0.001), 90天心脏替代治疗(HRT)或死亡的发生率更高(风险比2.52,95%可信区间(1.13-5.64);P = 0.024)。结论:超过四分之一的ADHF患者可新归类为VHF患者,其特征是住院时间延长,90天死亡率/ HRT率更差。标准化利尿剂方案的初始反应率很高。
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来源期刊
Israel Medical Association Journal
Israel Medical Association Journal 医学-医学:内科
CiteScore
2.20
自引率
12.50%
发文量
54
审稿时长
3-8 weeks
期刊介绍: The Israel Medical Association Journal (IMAJ), representing medical sciences and medicine in Israel, is published in English by the Israel Medical Association. The Israel Medical Association Journal (IMAJ) was initiated in 1999.
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