Proliferative verrucous leukoplakia and unifocal verrucous leukoplakia in China: a comparative retrospective cohort study.

IF 1.9 3区医学 Q2 DENTISTRY, ORAL SURGERY & MEDICINE

Oral Surgery Oral Medicine Oral Pathology Oral Radiology Pub Date : 2025-08-07 DOI:10.1016/j.oooo.2025.07.013

Shuangshuang Wu, Linman Li, Xu Wang, Zhimin Yan

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引用次数: 0

Abstract

Objective: There are limited data regarding the association and differentiation between proliferative verrucous leukoplakia (PVL) and unifocal verrucous leukoplakia (UVL).

Methods: We retrospectively recruited oral leukoplakia (OL) patients from 2010 to 2024, analyzing the demographic, clinical, histopathological features, and malignant transformation of PVL and UVL.

Results: Among 1756 OL subjects, PVL and UVL accounted for 1.88% and 1.54%, respectively, sharing features like similar age of onset and high dysplasia rates (57.58% vs 55.56%). However, significant differences still existed. Gender ratios were 1:2 in PVL and 2.34:1 in UVL. PVL had lower diagnostic accuracy due to lichenoid lesions in 69.70% of patients and higher biopsy counts (2.19 vs 1.19). Malignant transformation rates were higher in PVL (27.27% vs 11.11%), occurring on the gingiva, while in UVL, it was on the buccal mucosa and tongue.

Conclusions: PVL and UVL are distinct clinical entities, highlighting the critical need for clinicians to differentiate and closely monitor both.

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中国增殖性疣状白斑和单发性疣状白斑：一项比较回顾性队列研究。

目的：关于增殖性疣状白斑（PVL）和单发性疣状白斑（UVL）的关联和鉴别的资料有限。方法：回顾性收集2010 ~ 2024年口腔白斑（OL）患者，分析口腔白斑（PVL）和口腔白斑（UVL）的人口学、临床、组织病理学特征及恶性转化情况。结果：1756例OL患者中，PVL和UVL分别占1.88%和1.54%，具有发病年龄相近、发育不良发生率高的特点（57.58% vs 55.56%）。然而，显著差异仍然存在。PVL的性别比例为1:2，UVL为2.34:1。由于69.70%的患者有苔藓样病变，PVL的诊断准确性较低，活检计数较高（2.19 vs 1.19）。PVL的恶性转化率较高（27.27% vs 11.11%），发生在牙龈上，而UVL发生在颊粘膜和舌头上。结论：PVL和UVL是不同的临床实体，强调临床医生对两者进行区分和密切监测的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oral Surgery Oral Medicine Oral Pathology Oral Radiology DENTISTRY, ORAL SURGERY & MEDICINE-

CiteScore

3.80

自引率

6.90%

发文量

1217

审稿时长

2-4 weeks

期刊介绍： Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology is required reading for anyone in the fields of oral surgery, oral medicine, oral pathology, oral radiology or advanced general practice dentistry. It is the only major dental journal that provides a practical and complete overview of the medical and surgical techniques of dental practice in four areas. Topics covered include such current issues as dental implants, treatment of HIV-infected patients, and evaluation and treatment of TMJ disorders. The official publication for nine societies, the Journal is recommended for initial purchase in the Brandon Hill study, Selected List of Books and Journals for the Small Medical Library.