Diurnal Variations in Anterior Segment Parameters in Different Grades of Patients With Keratoconus.

IF 2.6 3区医学 Q2 OPHTHALMOLOGY

Translational Vision Science & Technology Pub Date : 2025-09-02 DOI:10.1167/tvst.14.9.15

Jinxuan Xiahou, Rui Ning, Shuoyu Xu, Kexin Li, Ingemar Gustafsson, Yiran Wang, Xinning Yang, Xingtao Zhou, Jinhai Huang

{"title":"Diurnal Variations in Anterior Segment Parameters in Different Grades of Patients With Keratoconus.","authors":"Jinxuan Xiahou, Rui Ning, Shuoyu Xu, Kexin Li, Ingemar Gustafsson, Yiran Wang, Xinning Yang, Xingtao Zhou, Jinhai Huang","doi":"10.1167/tvst.14.9.15","DOIUrl":null,"url":null,"abstract":"Purpose: This study aims to evaluate the diurnal variations in anterior segment parameters among patients with keratoconus (KC) and to compare these variations across different severity levels of the disease.Methods: A total of 82 patients with KC were included in the study. Corneal parameters were measured at 08:30, 11:30, 14:30, 17:30, and 20:30 using the Pentacam HR (Oculus, Wetzlar, Germany). The eyes were graded as mild, moderate, or severe KC according to the Topographical Keratoconus Classification system. The Kolmogorov-Smirnov test was applied to assess the normality of the data distribution. Diurnal variations in these parameters were analyzed using repeated-measures analysis of variance.Results: Significant diurnal variations were found in central corneal thickness (CCT) and thinnest corneal thickness (TCT) in patients with KC. The mean amplitude of change between 08:30 and 11:30 was 5.73 µm for CCT and 5.83 µm for TCT. These variations were significant in mild to moderate KC but not in severe KC. In addition, corneal volume showed significant diurnal variations in all KC, while keratometry and anterior chamber depth did not.Conclusions: The study highlights that significant diurnal variation in corneal and anterior chamber parameters, specifically CCT and TCT, is prominent in patients with KC, especially those with mild and moderate disease severity.Translational relevance: The results of the diurnal variation patterns of anterior segment parameters in patients with KC contribute to the evaluation of surgical safety and the assessment of follow-up progression. These research findings provide a basis for clinicians to better manage the condition of patients with KC.","PeriodicalId":23322,"journal":{"name":"Translational Vision Science & Technology","volume":"14 9","pages":"15"},"PeriodicalIF":2.6000,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12439498/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Translational Vision Science & Technology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1167/tvst.14.9.15","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: This study aims to evaluate the diurnal variations in anterior segment parameters among patients with keratoconus (KC) and to compare these variations across different severity levels of the disease.

Methods: A total of 82 patients with KC were included in the study. Corneal parameters were measured at 08:30, 11:30, 14:30, 17:30, and 20:30 using the Pentacam HR (Oculus, Wetzlar, Germany). The eyes were graded as mild, moderate, or severe KC according to the Topographical Keratoconus Classification system. The Kolmogorov-Smirnov test was applied to assess the normality of the data distribution. Diurnal variations in these parameters were analyzed using repeated-measures analysis of variance.

Results: Significant diurnal variations were found in central corneal thickness (CCT) and thinnest corneal thickness (TCT) in patients with KC. The mean amplitude of change between 08:30 and 11:30 was 5.73 µm for CCT and 5.83 µm for TCT. These variations were significant in mild to moderate KC but not in severe KC. In addition, corneal volume showed significant diurnal variations in all KC, while keratometry and anterior chamber depth did not.

Conclusions: The study highlights that significant diurnal variation in corneal and anterior chamber parameters, specifically CCT and TCT, is prominent in patients with KC, especially those with mild and moderate disease severity.

Translational relevance: The results of the diurnal variation patterns of anterior segment parameters in patients with KC contribute to the evaluation of surgical safety and the assessment of follow-up progression. These research findings provide a basis for clinicians to better manage the condition of patients with KC.

Abstract Image

查看原文本刊更多论文

不同级别圆锥角膜患者前节参数的日变化。

目的：本研究旨在评估圆锥角膜（KC）患者前段参数的日变化，并比较这些变化在不同严重程度的疾病。方法：选取82例KC患者作为研究对象。使用Pentacam HR （Oculus, Wetzlar，德国）于08:30、11:30、14:30、17:30和20:30测量角膜参数。根据地形圆锥角膜分类系统将眼睛分为轻度、中度或重度KC。采用Kolmogorov-Smirnov检验评估数据分布的正态性。使用重复测量方差分析分析这些参数的日变化。结果：KC患者角膜中央厚度（CCT）和最薄角膜厚度（TCT）在08:30 ~ 11:30之间有显著的日变化，CCT和TCT的平均变化幅度分别为5.73µm和5.83µm。这些变化在轻度至中度KC中很明显，但在重度KC中没有。此外，角膜体积在所有KC中都显示出显著的日变化，而角膜密度和前房深度则没有。结论：本研究强调角膜和前房参数，特别是CCT和TCT的显著日变化在KC患者，特别是轻、中度疾病严重程度的患者中表现突出。翻译相关性：KC患者前段参数的日变化模式的结果有助于评估手术安全性和评估随访进展。这些研究结果为临床医生更好地管理KC患者的病情提供了依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Translational Vision Science & Technology Engineering-Biomedical Engineering

CiteScore

5.70

自引率

3.30%

发文量

346

审稿时长

25 weeks

期刊介绍： Translational Vision Science & Technology (TVST), an official journal of the Association for Research in Vision and Ophthalmology (ARVO), an international organization whose purpose is to advance research worldwide into understanding the visual system and preventing, treating and curing its disorders, is an online, open access, peer-reviewed journal emphasizing multidisciplinary research that bridges the gap between basic research and clinical care. A highly qualified and diverse group of Associate Editors and Editorial Board Members is led by Editor-in-Chief Marco Zarbin, MD, PhD, FARVO. The journal covers a broad spectrum of work, including but not limited to: Applications of stem cell technology for regenerative medicine, Development of new animal models of human diseases, Tissue bioengineering, Chemical engineering to improve virus-based gene delivery, Nanotechnology for drug delivery, Design and synthesis of artificial extracellular matrices, Development of a true microsurgical operating environment, Refining data analysis algorithms to improve in vivo imaging technology, Results of Phase 1 clinical trials, Reverse translational ("bedside to bench") research. TVST seeks manuscripts from scientists and clinicians with diverse backgrounds ranging from basic chemistry to ophthalmic surgery that will advance or change the way we understand and/or treat vision-threatening diseases. TVST encourages the use of color, multimedia, hyperlinks, program code and other digital enhancements.