Distinct roles of TET-mediated cytosine oxidation in neural stem cell fate decisions.

IF 5.1 2区医学 Q1 CELL & TISSUE ENGINEERING

Stem Cell Reports Pub Date : 2025-09-09 DOI:10.1016/j.stemcr.2025.102614

Oren Ram

引用次数: 0

Abstract

Ten-eleven translocation (TET) enzymes regulate neural stem cell development via distinct cytosine oxidation steps. This study, by Ebert et al. reveals that hydroxymethylation is crucial for neurogenesis, while formylation and carboxylation drive gliogenesis, offering insights into TET biology and therapeutic potential in neurodevelopmental and neurodegenerative disorders.

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tet介导的胞嘧啶氧化在神经干细胞命运决定中的独特作用。

10 - 11易位（TET）酶通过不同的胞嘧啶氧化步骤调节神经干细胞的发育。Ebert等人的这项研究揭示了羟甲基化对神经发生至关重要，而甲酰化和羧化则驱动胶质发生，为TET生物学和神经发育和神经退行性疾病的治疗潜力提供了见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stem Cell Reports CELL & TISSUE ENGINEERING-CELL BIOLOGY

CiteScore

10.50

自引率

1.70%

发文量

200

审稿时长

28 weeks

期刊介绍： Stem Cell Reports publishes high-quality, peer-reviewed research presenting conceptual or practical advances across the breadth of stem cell research and its applications to medicine. Our particular focus on shorter, single-point articles, timely publication, strong editorial decision-making and scientific input by leaders in the field and a "scoop protection" mechanism are reasons to submit your best papers.