Visceral Adipose Tissue Cut-Points for Increased Metabolic Risk in Chinese Adults using Low Dose Computed Tomography: a Nationwide Multi-Centre Study.

IF 4.7 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Obesity Facts Pub Date : 2025-09-10 DOI:10.1159/000548333

Yandong Liu, Yanhui Lu, Yongli Li, Dong Yan, Yan Wu, Chunwei Wu, Limei Ran, Yong Lu, Kaiping Zhao, Glen M Blake, Mingzhu Zou, Xiaoguang Cheng, Min Chen

{"title":"Visceral Adipose Tissue Cut-Points for Increased Metabolic Risk in Chinese Adults using Low Dose Computed Tomography: a Nationwide Multi-Centre Study.","authors":"Yandong Liu, Yanhui Lu, Yongli Li, Dong Yan, Yan Wu, Chunwei Wu, Limei Ran, Yong Lu, Kaiping Zhao, Glen M Blake, Mingzhu Zou, Xiaoguang Cheng, Min Chen","doi":"10.1159/000548333","DOIUrl":null,"url":null,"abstract":"Introduction: Visceral adipose tissue (VAT) is a significant driver for metabolic disease risk. Low dose computed tomography (LDCT) imaging obtained for other clinical indications is useful for the opportunistic screening of osteoporosis and demonstrates additional potential for the screening of metabolic risk through the measurement of visceral adipose tissue. In this study, we explored LDCT-derived VAT and calculated VAT thresholds indicative of elevated metabolic risk in a population cohort of Chinese men and women.Methods: A total of 21,772 adults (64.2% men, 35.8% women) received a LDCT chest scan for routine lung cancer screening between 2018 and 2019, and abdominal VAT area (L2 region) was derived from these scans using QCT software. The presence of metabolic syndrome (MetS) was ascertained from clinical records and based on the Chinese national guidelines. All data for this current study were obtained from the China Biobank Project, a prospective, nationwide, multi center population study.Results: MetS was prevalent in 29.5% of men and 10.5% of women. Using ROC curves, the optimum VAT area cut-points to identify MetS were 213 cm2 in men (OR 6.15, 95%CI 5.65 - 6.69) and 136 cm2 in women (OR 9.25, 95%CI 7.58 - 11.4). A further analysis of population attributable risk showed that VAT above threshold was significantly associated with an increased risk for metabolic syndrome. A population attributable risk for MetS by VAT area above sex-specific cut-points was 70.9% in men and 74.1% in women.Conclusion: LDCT-based opportunistic screening could identify patients at increased risk of MetS through the evaluation of VAT area and application of sex-specific VAT cut-points. Future cohort studies are needed to ascertain the clinical utility and health economic benefits of the derived cut-points in terms of the prevention of MetS and associated morbidity and mortality.","PeriodicalId":19414,"journal":{"name":"Obesity Facts","volume":" ","pages":"1-22"},"PeriodicalIF":4.7000,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity Facts","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000548333","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"ENDOCRINOLOGY & METABOLISM","Score":null,"Total":0}

引用次数: 0

Abstract

Introduction: Visceral adipose tissue (VAT) is a significant driver for metabolic disease risk. Low dose computed tomography (LDCT) imaging obtained for other clinical indications is useful for the opportunistic screening of osteoporosis and demonstrates additional potential for the screening of metabolic risk through the measurement of visceral adipose tissue. In this study, we explored LDCT-derived VAT and calculated VAT thresholds indicative of elevated metabolic risk in a population cohort of Chinese men and women.

Methods: A total of 21,772 adults (64.2% men, 35.8% women) received a LDCT chest scan for routine lung cancer screening between 2018 and 2019, and abdominal VAT area (L2 region) was derived from these scans using QCT software. The presence of metabolic syndrome (MetS) was ascertained from clinical records and based on the Chinese national guidelines. All data for this current study were obtained from the China Biobank Project, a prospective, nationwide, multi center population study.

Results: MetS was prevalent in 29.5% of men and 10.5% of women. Using ROC curves, the optimum VAT area cut-points to identify MetS were 213 cm2 in men (OR 6.15, 95%CI 5.65 - 6.69) and 136 cm2 in women (OR 9.25, 95%CI 7.58 - 11.4). A further analysis of population attributable risk showed that VAT above threshold was significantly associated with an increased risk for metabolic syndrome. A population attributable risk for MetS by VAT area above sex-specific cut-points was 70.9% in men and 74.1% in women.

Conclusion: LDCT-based opportunistic screening could identify patients at increased risk of MetS through the evaluation of VAT area and application of sex-specific VAT cut-points. Future cohort studies are needed to ascertain the clinical utility and health economic benefits of the derived cut-points in terms of the prevention of MetS and associated morbidity and mortality.

查看原文本刊更多论文

使用低剂量计算机断层扫描发现中国成人内脏脂肪组织切点增加代谢风险：一项全国性多中心研究。

内脏脂肪组织（VAT）是代谢性疾病风险的重要驱动因素。用于其他临床适应症的低剂量计算机断层扫描（LDCT）成像可用于骨质疏松症的机会性筛查，并通过测量内脏脂肪组织显示出筛查代谢风险的额外潜力。在这项研究中，我们探讨了ldct衍生的增值税，并计算了表明中国男性和女性人群中代谢风险升高的增值税阈值。方法：在2018年至2019年期间，共有21772名成年人（男性64.2%，女性35.8%）接受了LDCT胸部扫描进行常规肺癌筛查，并使用QCT软件从这些扫描中获得腹部VAT区域（L2区域）。根据临床记录和中国国家指南确定代谢综合征（MetS）的存在。本研究的所有数据均来自中国生物库项目，这是一项前瞻性、全国性、多中心的人口研究。结果：met在29.5%的男性和10.5%的女性中普遍存在。使用ROC曲线，识别MetS的最佳增值区切点男性为213 cm2 (OR 6.15, 95%CI 5.65 - 6.69)，女性为136 cm2 （OR 9.25, 95%CI 7.58 - 11.4）。对人群归因风险的进一步分析表明，增值税高于阈值与代谢综合征风险增加显著相关。在男性和女性中，高于性别切割点的VAT区域的met人群归因风险分别为70.9%和74.1%。结论：基于ldct的机会性筛查可以通过评估VAT区域和应用性别特异性VAT切点来识别MetS风险增加的患者。未来的队列研究需要确定在预防MetS和相关发病率和死亡率方面衍生的切割点的临床效用和健康经济效益。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Obesity Facts 医学-内分泌学与代谢

CiteScore

6.80

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： ''Obesity Facts'' publishes articles covering all aspects of obesity, in particular epidemiology, etiology and pathogenesis, treatment, and the prevention of adiposity. As obesity is related to many disease processes, the journal is also dedicated to all topics pertaining to comorbidity and covers psychological and sociocultural aspects as well as influences of nutrition and exercise on body weight. The editors carefully select papers to present only the most recent findings in clinical practice and research. All professionals concerned with obesity issues will find this journal a most valuable update to keep them abreast of the latest scientific developments.