Management of preterm premature rupture of membranes: Antimicrobial stewardship and novel therapeutic strategies

IF 1.5 4区医学 Q3 OBSTETRICS & GYNECOLOGY

Journal of Obstetrics and Gynaecology Research Pub Date : 2025-09-10 DOI:10.1111/jog.70020

Ya-Wen Zhong, Xiu-Fang Wang, Hong Ding, Sui-Jin Zheng, Cai-Hong Wang, Rui-Man Li

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引用次数: 0

Abstract

Purpose

Preterm premature rupture of membranes (PPROM) is a major contributor to preterm birth and is associated with increased risks of maternal and neonatal complications. The aim of this review is to summarize current antibiotic strategies and explore emerging adjunctive therapies, including probiotics, amnioinfusion, and fetal membrane repair, to improve the management of PPROM.

Methods

Relevant literature on antibiotic therapy for PPROM and emerging treatment strategies was systematically retrieved from PubMed. The data were analyzed to compare standard antibiotic protocols with personalized and combination regimens.

Results

Evidence indicates that adjusting antibiotic duration and adopting precision-based regimens may improve clinical efficacy while minimizing adverse effects. Moreover, probiotics, amnioinfusion, and fetal membrane repair hold promise in alleviating infection-related inflammation and improving pregnancy outcomes.

Conclusions

Optimizing antibiotic therapy via individualized approaches and incorporating adjunctive treatments could enhance the management of PPROM. Future research ought to concentrate on pinpointing biomarkers for personalized antibiotic selection, evaluating combination therapies, and assessing long-term maternal–fetal outcomes.

Abstract Image

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管理早产早破膜：抗菌管理和新的治疗策略。

前言：目的：早产胎膜早破（PPROM）是早产的主要因素，并与孕产妇和新生儿并发症的风险增加有关。本综述的目的是总结目前的抗生素策略，并探索新的辅助治疗方法，包括益生菌，羊膜输注和胎膜修复，以改善PPROM的管理。方法：系统检索PubMed关于PPROM抗生素治疗的相关文献及新兴治疗策略。对数据进行分析，比较标准抗生素方案与个性化和联合方案。结果：有证据表明，调整抗生素疗程和采用精准用药方案可提高临床疗效，同时最大限度地减少不良反应。此外，益生菌、羊膜输注和胎膜修复在减轻感染相关炎症和改善妊娠结局方面有希望。结论：个体化优化抗生素治疗并结合辅助治疗可提高PPROM的治疗效果。未来的研究应该集中在确定个性化抗生素选择的生物标志物，评估联合治疗，以及评估母胎长期结局。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obstetrics and Gynaecology Research 医学-妇产科学

CiteScore

3.10

自引率

0.00%

发文量

376

审稿时长

3-6 weeks

期刊介绍： The Journal of Obstetrics and Gynaecology Research is the official Journal of the Asia and Oceania Federation of Obstetrics and Gynecology and of the Japan Society of Obstetrics and Gynecology, and aims to provide a medium for the publication of articles in the fields of obstetrics and gynecology. The Journal publishes original research articles, case reports, review articles and letters to the editor. The Journal will give publication priority to original research articles over case reports. Accepted papers become the exclusive licence of the Journal. Manuscripts are peer reviewed by at least two referees and/or Associate Editors expert in the field of the submitted paper.