Bacterial porphyrins in healthy skin: Microbiota components impact melanogenesis and age-related processes leading to Porphyr'ageing.

IF 2.5 4区 医学 Q2 DERMATOLOGY
Marie Meunier, Morgane De Tollenaere, Cyrille Jarrin, Emilie Chapuis, Marine Bracq, Laura Lapierre, Catherine Zanchetta, Jean Tiguemounine, Amandine Scandolera, Romain Reynaud
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Abstract

Objective: Porphyrins are ubiquitous metabolites and are constitutive of the bacterial metabolome of healthy skin. Their consideration has until now been limited to their pro-inflammatory activity in acne vulgaris. The present work suggests a new role for these molecules in the onset of skin ageing.

Methods: A mixture of coproporphyrin III and protoporphyrin IX, representative of skin microbiota metabolites, was defined and applied in different skin models. Finally, an in vivo study was conducted to determine the association between porphyrin's abundance and ageing signs.

Results: Bacterial porphyrins penetrated stratum corneum and reached living epidermal cells. The porphyrin mixture increased IL-8, ROS and melanin contents. Porphyrin-induced melanin synthesis appeared to be regulated by translocator protein TSPO/PBR. In fibroblasts, bacterial metabolites down-regulated a set of transcripts involved in extracellular matrix architecture and associated with ageing, which was confirmed by a decrease of type I pro-collagen. Finally, the clinical study established positive and significant correlations between porphyrin abundance and the severity of ageing signs, including invisible spots, brown spots and wrinkles length.

Conclusion: In summary, porphyrins could play unexpected roles in skin's premature ageing process, a phenomenon we propose to call Porphyr'ageing, that promotes hyperpigmentation, inflammation, oxidative stress and fibroblast cell ageing, leading to dermal matrix weakening.

健康皮肤中的细菌卟啉:微生物群成分影响黑色素生成和与年龄相关的过程,导致卟啉老化。
目的:卟啉是普遍存在的代谢产物,是健康皮肤细菌代谢组的组成部分。到目前为止,他们的考虑仅限于他们对寻常痤疮的促炎活性。目前的研究表明,这些分子在皮肤老化过程中起着新的作用。方法:定义具有代表性的皮肤微生物代谢物coproporphyrin III和protoporphyrin IX的混合物,并应用于不同的皮肤模型。最后,进行了一项体内研究,以确定卟啉的丰度与衰老迹象之间的关系。结果:细菌卟啉能穿透角质层到达活表皮细胞。卟啉混合物增加了IL-8、ROS和黑色素含量。卟啉诱导的黑色素合成似乎受转运蛋白TSPO/PBR的调控。在成纤维细胞中,细菌代谢物下调了一组与细胞外基质结构相关并与衰老相关的转录物,这被I型前胶原蛋白的减少所证实。最后,临床研究建立了卟啉丰度与衰老迹象的严重程度,包括隐形斑、褐斑和皱纹长度之间的正相关和显著相关。结论:综上所述,卟啉在皮肤的过早衰老过程中发挥了意想不到的作用,我们将这种现象称为卟啉老化,它促进色素沉着、炎症、氧化应激和成纤维细胞老化,导致真皮基质减弱。
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来源期刊
CiteScore
4.60
自引率
4.30%
发文量
73
期刊介绍: The Journal publishes original refereed papers, review papers and correspondence in the fields of cosmetic research. It is read by practising cosmetic scientists and dermatologists, as well as specialists in more diverse disciplines that are developing new products which contact the skin, hair, nails or mucous membranes. The aim of the Journal is to present current scientific research, both pure and applied, in: cosmetics, toiletries, perfumery and allied fields. Areas that are of particular interest include: studies in skin physiology and interactions with cosmetic ingredients, innovation in claim substantiation methods (in silico, in vitro, ex vivo, in vivo), human and in vitro safety testing of cosmetic ingredients and products, physical chemistry and technology of emulsion and dispersed systems, theory and application of surfactants, new developments in olfactive research, aerosol technology and selected aspects of analytical chemistry.
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