The role of the transcription factor PATZ1 in tumorigenesis and metabolic regulation.

IF 2.8 3区 医学 Q3 ONCOLOGY
Yin Zheng, Jiabo Chen, Cheng Su
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引用次数: 0

Abstract

PATZ1 (POZ/BTB and AT hook containing zinc finger 1) is an important member of the POZ/BTB (Poxvirus and Zinc finger / Broad-complex, Tramtrack, and Bric-à-brac) family and has been confirmed to be involved in the development and progression of various tumors. Moreover, differential expression of PATZ1 is associated with the prognosis of multiple cancers and systemic metabolic patterns. It participates in the regulation of oncogenes and a range of biological processes, including glucose and lipid metabolism. This review aims to summarize the current understanding of the relationship between the transcription factor PATZ1, tumorigenesis, and metabolism, with the goal of providing a theoretical basis for the development of PATZ1-targeted therapies.

Abstract Image

Abstract Image

转录因子PATZ1在肿瘤发生和代谢调节中的作用。
PATZ1 (POZ/BTB和AT hook containing zinc finger 1)是POZ/BTB (Poxvirus and zinc finger / Broad-complex, Tramtrack, Bric-à-brac)家族的重要成员,已被证实参与多种肿瘤的发生和进展。此外,PATZ1的差异表达与多种癌症的预后和全身代谢模式有关。它参与致癌基因和一系列生物过程的调节,包括葡萄糖和脂质代谢。本文综述了目前对转录因子PATZ1与肿瘤发生、代谢之间关系的认识,旨在为开发PATZ1靶向治疗提供理论依据。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
4.00
自引率
2.80%
发文量
577
审稿时长
2 months
期刊介绍: The "Journal of Cancer Research and Clinical Oncology" publishes significant and up-to-date articles within the fields of experimental and clinical oncology. The journal, which is chiefly devoted to Original papers, also includes Reviews as well as Editorials and Guest editorials on current, controversial topics. The section Letters to the editors provides a forum for a rapid exchange of comments and information concerning previously published papers and topics of current interest. Meeting reports provide current information on the latest results presented at important congresses. The following fields are covered: carcinogenesis - etiology, mechanisms; molecular biology; recent developments in tumor therapy; general diagnosis; laboratory diagnosis; diagnostic and experimental pathology; oncologic surgery; and epidemiology.
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